Protein protein interactions involving activated RAB1:GTP help dock the ER-derived vesicle on the cis-Golgi membrane (reviewed in Lord et al, 2013) . Independently, RAB:GTP interacts with both the USO1 homodimer (a long coiled coil tethering factor also known as p115) and the GOLGA2 component of the GOLGA2:GORASP1 complex on the cis-Golgi membrane (Allan et al, 2000; Moyer et al, 2001; Weide et al, 2001). USO1 also contacts GOLGA2 directly (Nakamura et al, 1997; Seeman et al, 2000). t-SNARES such as STX5, GOSR1and GOSR2 also participate in this complex on the cis-ERGIC membrane (Brandon et al, 2006; Shorter et al, 2002; reviewed in Brandizzi and Barlowe, 2013).
Brandizzi, F, Barlowe, C
Allan, BB, Balch, WE, Moyer, BD
Warren, G, Levine, TP, Lowe, M, Rabouille, C, Nakamura, N
Warren, G, Dirac-Svejstrup, AB, Beard, MB, Seemann, J, Shorter, J
Ferro-Novick, S, Miller, EA, Lord, C
Grabski, R, Sztul, E, Kawai, R, Szul, T, Alvarez, C, Brandon, E, Benjamin, R
Weide, T, Köster, M, Barnekow, A, Bayer, M, Siebrasse, JP, Peters, R
Seemann, J, Jokitalo, EJ, Warren, G
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