Reactome | RAB1:GTP binds USO1 and GORASP1:GOLGA2

RAB1:GTP binds USO1 and GORASP1:GOLGA2

Stable Identifier

R-HSA-5694418

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)

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Protein protein interactions involving activated RAB1:GTP help dock the ER-derived vesicle on the cis-Golgi membrane (reviewed in Lord et al, 2013) . Independently, RAB:GTP interacts with both the USO1 homodimer (a long coiled coil tethering factor also known as p115) and the GOLGA2 component of the GOLGA2:GORASP1 complex on the cis-Golgi membrane (Allan et al, 2000; Moyer et al, 2001; Weide et al, 2001). USO1 also contacts GOLGA2 directly (Nakamura et al, 1997; Seeman et al, 2000). t-SNARES such as STX5, GOSR1and GOSR2 also participate in this complex on the cis-ERGIC membrane (Brandon et al, 2006; Shorter et al, 2002; reviewed in Brandizzi and Barlowe, 2013).

Literature References

PubMed ID	Title	Journal	Year
23698585	Organization of the ER-Golgi interface for membrane traffic control Brandizzi, F, Barlowe, C	Nat. Rev. Mol. Cell Biol.	2013
11285137	Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering Allan, BB, Balch, WE, Moyer, BD	Traffic	2001
9150144	The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner Warren, G, Levine, TP, Lowe, M, Rabouille, C, Nakamura, N	Cell	1997
11927603	Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 Warren, G, Dirac-Svejstrup, AB, Beard, MB, Seemann, J, Shorter, J	J. Cell Biol.	2002
23378591	The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Ferro-Novick, S, Miller, EA, Lord, C	Cold Spring Harb Perspect Biol	2013
16624868	On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo Grabski, R, Sztul, E, Kawai, R, Szul, T, Alvarez, C, Brandon, E, Benjamin, R	Mol. Biol. Cell	2006
11306556	The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b Weide, T, Köster, M, Barnekow, A, Bayer, M, Siebrasse, JP, Peters, R	EMBO Rep.	2001
10679020	The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo Seemann, J, Jokitalo, EJ, Warren, G	Mol. Biol. Cell	2000
10903204	Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion Allan, BB, Balch, WE, Moyer, BD	Science	2000