Stable Identifier
Reaction [binding]
Homo sapiens
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Protein protein interactions involving activated RAB1:GTP help dock the ER-derived vesicle on the cis-Golgi membrane (reviewed in Lord et al, 2013) . Independently, RAB:GTP interacts with both the USO1 homodimer (a long coiled coil tethering factor also known as p115) and the GOLGA2 component of the GOLGA2:GORASP1 complex on the cis-Golgi membrane (Allan et al, 2000; Moyer et al, 2001; Weide et al, 2001). USO1 also contacts GOLGA2 directly (Nakamura et al, 1997; Seeman et al, 2000). t-SNARES such as STX5, GOSR1and GOSR2 also participate in this complex on the cis-ERGIC membrane (Brandon et al, 2006; Shorter et al, 2002; reviewed in Brandizzi and Barlowe, 2013).
Literature References
PubMed ID Title Journal Year
23698585 Organization of the ER-Golgi interface for membrane traffic control

Brandizzi, F, Barlowe, C

Nat. Rev. Mol. Cell Biol. 2013
11285137 Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering

Allan, BB, Balch, WE, Moyer, BD

Traffic 2001
9150144 The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner

Warren, G, Levine, TP, Lowe, M, Rabouille, C, Nakamura, N

Cell 1997
11927603 Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115

Warren, G, Dirac-Svejstrup, AB, Beard, MB, Seemann, J, Shorter, J

J. Cell Biol. 2002
23378591 The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi

Ferro-Novick, S, Miller, EA, Lord, C

Cold Spring Harb Perspect Biol 2013
16624868 On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo

Grabski, R, Sztul, E, Kawai, R, Szul, T, Alvarez, C, Brandon, E, Benjamin, R

Mol. Biol. Cell 2006
11306556 The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b

Weide, T, Köster, M, Barnekow, A, Bayer, M, Siebrasse, JP, Peters, R

EMBO Rep. 2001
10679020 The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo

Seemann, J, Jokitalo, EJ, Warren, G

Mol. Biol. Cell 2000
10903204 Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion

Allan, BB, Balch, WE, Moyer, BD

Science 2000
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