SEC24A,B:SEC23A bind SEC22B

Stable Identifier
R-HSA-5694415
Type
Reaction
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
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Summation

Of the four human SEC24 isoforms, SEC24A and B are required for packaging the v-SNARE SEC22 into COPII vesicles. Recognition of the ER packaging epitope on SEC22 also depends on SEC23A (Mancias and Goldberg, 2007).

Literature References
PubMed ID Title Journal Year
17499046 The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope

Mancias, JD, Goldberg, J

Mol. Cell 2007
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
SEC24A,B:SEC23A bind SEC22B (Arabidopsis thaliana)
SEC24A,B:SEC23A bind SEC22B (Bos taurus)
SEC24A,B:SEC23A bind SEC22B (Caenorhabditis elegans)
SEC24A,B:SEC23A bind SEC22B (Canis familiaris)
SEC24A,B:SEC23A bind SEC22B (Danio rerio)
SEC24A,B:SEC23A bind SEC22B (Dictyostelium discoideum)
SEC24A,B:SEC23A bind SEC22B (Drosophila melanogaster)
SEC24A,B:SEC23A bind SEC22B (Gallus gallus)
SEC24A,B:SEC23A bind SEC22B (Mus musculus)
SEC24A,B:SEC23A bind SEC22B (Oryza sativa)
SEC24A,B:SEC23A bind SEC22B (Plasmodium falciparum)
SEC24A,B:SEC23A bind SEC22B (Rattus norvegicus)
SEC24A,B:SEC23A bind SEC22B (Saccharomyces cerevisiae)
SEC24A,B:SEC23A bind SEC22B (Schizosaccharomyces pombe)
SEC24A,B:SEC23A bind SEC22B (Sus scrofa)
SEC24A,B:SEC23A bind SEC22B (Taeniopygia guttata)
SEC24A,B:SEC23A bind SEC22B (Xenopus tropicalis)
Authored
Rothfels, K  (2015-04-18)
Reviewed
Gillespie, ME  (2015-08-18)