Reactome | TMED2:TMED10 tetramer binds GPI anchored proteins

TMED2:TMED10 tetramer binds GPI anchored proteins

Stable Identifier

R-HSA-5694410

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)

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TMED2:TMED10 tetramer binds GPI anchored proteins

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TMED2 and TMED10 are members of the p24 family of proteins that bind GPI anchored proteins in the ER and mediate their incorporation into COPII vesicles (Bonnon et al, 2010; reviewed in Strating et al, 2009). p24 proteins function as heteromeric complexes and interact with components of the COPII coat (Jenne et al, 2002; Dominguez et al, 1998; reviewed in Strating et al, 2009). In complex with LMAN1 and SURF4, they also play a role in maintaining the structure of the ERGIC (Mitrovic et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18287528	The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi Koegler, E, Hauri, HP, Ben-Tekaya, H, Gruenberg, J, Mitrovic, S	Mol. Biol. Cell	2008
12237308	Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway Frey, K, Jenne, N, Brugger, B, Wieland, FT	J. Biol. Chem.	2002
9472029	gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer Paccaud, JP, Dejgaard, K, Fazel, A, Thomas, DY, Dahan, S, Füllekrug, J, Dominguez, M, Nilsson, T, Bergeron, JJ	J. Cell Biol.	1998
20427317	Selective export of human GPI-anchored proteins from the endoplasmic reticulum Hauri, HP, Wendeler, MW, Bonnon, C, Paccaud, JP	J. Cell. Sci.	2010
19566487	The p24 family and selective transport processes at the ER-Golgi interface Strating, JR, Martens, GJ	Biol. Cell	2009