Reactome | TMED2:TMED10 tetramer binds GPI anchored proteins

TMED2:TMED10 tetramer binds GPI anchored proteins

Stable Identifier

R-HSA-5694410

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)

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TMED2:TMED10 tetramer binds GPI anchored proteins

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TMED2 and TMED10 are members of the p24 family of proteins that bind GPI anchored proteins in the ER and mediate their incorporation into COPII vesicles (Bonnon et al, 2010; reviewed in Strating et al, 2009). p24 proteins function as heteromeric complexes and interact with components of the COPII coat (Jenne et al, 2002; Dominguez et al, 1998; reviewed in Strating et al, 2009). In complex with LMAN1 and SURF4, they also play a role in maintaining the structure of the ERGIC (Mitrovic et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18287528	The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi Mitrovic, S, Ben-Tekaya, H, Koegler, E, Gruenberg, J, Hauri, HP	Mol. Biol. Cell	2008
12237308	Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway Jenne, N, Frey, K, Brugger, B, Wieland, FT	J. Biol. Chem.	2002
9472029	gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer Dominguez, M, Dejgaard, K, Füllekrug, J, Dahan, S, Fazel, A, Paccaud, JP, Thomas, DY, Bergeron, JJ, Nilsson, T	J. Cell Biol.	1998
20427317	Selective export of human GPI-anchored proteins from the endoplasmic reticulum Bonnon, C, Wendeler, MW, Paccaud, JP, Hauri, HP	J. Cell. Sci.	2010
19566487	The p24 family and selective transport processes at the ER-Golgi interface Strating, JR, Martens, GJ	Biol. Cell	2009