TMED2 and TMED10 are members of the p24 family of proteins that bind GPI anchored proteins in the ER and mediate their incorporation into COPII vesicles (Bonnon et al, 2010; reviewed in Strating et al, 2009). p24 proteins function as heteromeric complexes and interact with components of the COPII coat (Jenne et al, 2002; Dominguez et al, 1998; reviewed in Strating et al, 2009). In complex with LMAN1 and SURF4, they also play a role in maintaining the structure of the ERGIC (Mitrovic et al, 2008).
Koegler, E, Hauri, HP, Ben-Tekaya, H, Gruenberg, J, Mitrovic, S
Frey, K, Jenne, N, Brugger, B, Wieland, FT
Paccaud, JP, Dejgaard, K, Fazel, A, Thomas, DY, Dahan, S, Füllekrug, J, Dominguez, M, Nilsson, T, Bergeron, JJ
Hauri, HP, Wendeler, MW, Bonnon, C, Paccaud, JP
Strating, JR, Martens, GJ
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