TMED2 and TMED10 are members of the p24 family of proteins that bind GPI anchored proteins in the ER and mediate their incorporation into COPII vesicles (Bonnon et al, 2010; reviewed in Strating et al, 2009). p24 proteins function as heteromeric complexes and interact with components of the COPII coat (Jenne et al, 2002; Dominguez et al, 1998; reviewed in Strating et al, 2009). In complex with LMAN1 and SURF4, they also play a role in maintaining the structure of the ERGIC (Mitrovic et al, 2008).
Jenne, N, Frey, K, Brugger, B, Wieland, FT
Mitrovic, S, Ben-Tekaya, H, Koegler, E, Gruenberg, J, Hauri, HP
Dominguez, M, Dejgaard, K, Füllekrug, J, Dahan, S, Fazel, A, Paccaud, JP, Thomas, DY, Bergeron, JJ, Nilsson, T
Bonnon, C, Wendeler, MW, Paccaud, JP, Hauri, HP
Strating, JR, Martens, GJ
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