TMED2:TMED10 tetramer binds GPI anchored proteins

Stable Identifier
R-HSA-5694410
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TMED2 and TMED10 are members of the p24 family of proteins that bind GPI anchored proteins in the ER and mediate their incorporation into COPII vesicles (Bonnon et al, 2010; reviewed in Strating et al, 2009). p24 proteins function as heteromeric complexes and interact with components of the COPII coat (Jenne et al, 2002; Dominguez et al, 1998; reviewed in Strating et al, 2009). In complex with LMAN1 and SURF4, they also play a role in maintaining the structure of the ERGIC (Mitrovic et al, 2008).

Literature References
PubMed ID Title Journal Year
12237308 Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway

Jenne, N, Frey, K, Brugger, B, Wieland, FT

J. Biol. Chem. 2002
18287528 The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi

Mitrovic, S, Ben-Tekaya, H, Koegler, E, Gruenberg, J, Hauri, HP

Mol. Biol. Cell 2008
9472029 gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer

Dominguez, M, Dejgaard, K, F├╝llekrug, J, Dahan, S, Fazel, A, Paccaud, JP, Thomas, DY, Bergeron, JJ, Nilsson, T

J. Cell Biol. 1998
20427317 Selective export of human GPI-anchored proteins from the endoplasmic reticulum

Bonnon, C, Wendeler, MW, Paccaud, JP, Hauri, HP

J. Cell. Sci. 2010
19566487 The p24 family and selective transport processes at the ER-Golgi interface

Strating, JR, Martens, GJ

Biol. Cell 2009
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