TMED2:TMED10 tetramer binds GPI anchored proteins

Stable Identifier
Reaction [binding]
Homo sapiens
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TMED2 and TMED10 are members of the p24 family of proteins that bind GPI anchored proteins in the ER and mediate their incorporation into COPII vesicles (Bonnon et al, 2010; reviewed in Strating et al, 2009). p24 proteins function as heteromeric complexes and interact with components of the COPII coat (Jenne et al, 2002; Dominguez et al, 1998; reviewed in Strating et al, 2009). In complex with LMAN1 and SURF4, they also play a role in maintaining the structure of the ERGIC (Mitrovic et al, 2008).
Literature References
PubMed ID Title Journal Year
18287528 The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi

Koegler, E, Hauri, HP, Ben-Tekaya, H, Gruenberg, J, Mitrovic, S

Mol. Biol. Cell 2008
12237308 Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway

Frey, K, Jenne, N, Brugger, B, Wieland, FT

J. Biol. Chem. 2002
9472029 gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer

Paccaud, JP, Dejgaard, K, Fazel, A, Thomas, DY, Dahan, S, F├╝llekrug, J, Dominguez, M, Nilsson, T, Bergeron, JJ

J. Cell Biol. 1998
20427317 Selective export of human GPI-anchored proteins from the endoplasmic reticulum

Hauri, HP, Wendeler, MW, Bonnon, C, Paccaud, JP

J. Cell. Sci. 2010
19566487 The p24 family and selective transport processes at the ER-Golgi interface

Strating, JR, Martens, GJ

Biol. Cell 2009
Orthologous Events
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