Reactome | Nucleotide exchange on RAB1

Nucleotide exchange on RAB1

Stable Identifier

R-HSA-5694409

Type

Reaction [transition]

Species

Homo sapiens

Compartment

COPII-coated ER to Golgi transport vesicle

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)

General

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The TRAPPC complex acts as a guanine-nucleotide exchange factor for RAB1, activating it (Yamasaki et al, 2009; reviewed in Brunet and Sacher, 2014).

Literature References

PubMed ID	Title	Journal	Year
19656848	mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles Klumperman, J, Oorschot, V, Ferro-Novick, S, Yu, S, Yamasaki, A, Meerloo, T, Menon, S, Satoh, A, Barrowman, J	Mol. Biol. Cell	2009
24917561	In sickness and in health: the role of TRAPP and associated proteins in disease Sacher, M, Brunet, S	Traffic	2014

Participants

Input

Output

Participates

as an event of

COPII-mediated vesicle transport (Homo sapiens)

Catalyst Activity

guanyl-nucleotide exchange factor activity of COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle]

Physical Entity

COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)

Activity

guanyl-nucleotide exchange factor activity (GO:0005085)

Orthologous Events

Nucleotide exchange on RAB1 (Bos taurus)

Nucleotide exchange on RAB1 (Caenorhabditis elegans)

Nucleotide exchange on RAB1 (Canis familiaris)

Nucleotide exchange on RAB1 (Danio rerio)

Nucleotide exchange on RAB1 (Dictyostelium discoideum)

Nucleotide exchange on RAB1 (Drosophila melanogaster)

Nucleotide exchange on RAB1 (Gallus gallus)