Nucleotide exchange on RAB1

Stable Identifier
R-HSA-5694409
Type
Reaction
Species
Homo sapiens
Compartment
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The TRAPPC complex acts as a guanine-nucleotide exchange factor for RAB1, activating it (Yamasaki et al, 2009; reviewed in Brunet and Sacher, 2014).

Literature References
PubMed ID Title Journal Year
19656848 mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles

Klumperman, J, Oorschot, V, Ferro-Novick, S, Yu, S, Yamasaki, A, Meerloo, T, Menon, S, Satoh, A, Barrowman, J

Mol. Biol. Cell 2009
24917561 In sickness and in health: the role of TRAPP and associated proteins in disease

Sacher, M, Brunet, S

Traffic 2014
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle]

Orthologous Events
Authored
Reviewed
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