XK:KEL:Zn2+ cleaves EDN3

Stable Identifier
R-HSA-5694082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The Kell blood group glycoprotein (KEL) is a zinc endopeptidase with endothelin-3-converting enzyme activity which can preferentially cleave endothelin-3 (EDN3), an endothelium-derived vasoconstrictor peptide. EDN3 is cleaved at Trp21-Ile22 to form the bioactive peptide EDN3(97-117) (Lee et al. 1999). KEL forms a heterodimer with membrane transport protein XK (Russo et al. 1998).

Literature References
PubMed ID Title Journal Year
9593744 Association of XK and Kell blood group proteins

Russo, D, Redman, C, Lee, S

J. Biol. Chem. 1998
10438732 Proteolytic processing of big endothelin-3 by the kell blood group protein

Lee, S, Lin, M, Mele, A, Cao, Y, Farmar, J, Russo, D, Redman, C

Blood 1999
Participants
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Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of XK:KEL:Zn2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
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