XK:KEL:Zn2+ cleaves EDN3

Stable Identifier
R-HSA-5694082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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XK:KEL:Zn2+ cleaves EDN3
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The Kell blood group glycoprotein (KEL) is a zinc endopeptidase with endothelin-3-converting enzyme activity which can preferentially cleave endothelin-3 (EDN3), an endothelium-derived vasoconstrictor peptide. EDN3 is cleaved at Trp21-Ile22 to form the bioactive peptide EDN3(97-117) (Lee et al. 1999). KEL forms a heterodimer with membrane transport protein XK (Russo et al. 1998).
Literature References
PubMed ID Title Journal Year
10438732 Proteolytic processing of big endothelin-3 by the kell blood group protein

Mele, A, Russo, D, Farmar, J, Redman, C, Lee, S, Lin, M, Cao, Y

Blood 1999
9593744 Association of XK and Kell blood group proteins

Russo, D, Redman, C, Lee, S

J. Biol. Chem. 1998
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Catalyst Activity

metalloendopeptidase activity of XK:KEL:Zn2+ [plasma membrane]

Physical Entity
XK:KEL:Zn2+ [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
XK:KEL:Zn2+ cleaves EDN3 (Canis familiaris)
XK:KEL:Zn2+ cleaves EDN3 (Gallus gallus)
XK:KEL:Zn2+ cleaves EDN3 (Mus musculus)
XK:KEL:Zn2+ cleaves EDN3 (Rattus norvegicus)
XK:KEL:Zn2+ cleaves EDN3 (Sus scrofa)
Authored
Jassal, B  (2015-05-21)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-21)
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