Reactome | EPHX1 hydrates BaP4,5O to BaP4,5-DHD

EPHX1 hydrates BaP4,5O to BaP4,5-DHD

Stable Identifier

R-HSA-5694077

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Microsomal epoxide hydrolase 1 (EPHX1) is involved in the metabolism of many potentially carcinogenic and/or genotoxic epoxides, such as those derived from the oxidation of polyaromatic hydrocarbons. It catalyses the hydration of arene and aliphatic epoxides to less reactive and more water-soluble dihydrodiols. An example substrate is epoxide benzo(a)pyrene 4,5-oxide (BaP4,5O), hydrated to benzo(a)pyrene 4,5-dihydrodiol (BaP4,5DHD) (Hosagrahara et al. 2004, Fretland & Omiecinski 2000).

Literature References

PubMed ID	Title	Journal	Year
11154734	Epoxide hydrolases: biochemistry and molecular biology Fretland, AJ, Omiecinski, CJ	Chem. Biol. Interact.	2000
15535985	Functional analysis of human microsomal epoxide hydrolase genetic variants Hassett, C, Hosagrahara, VP, Omiecinski, CJ, Rettie, AE	Chem. Biol. Interact.	2004