FUT3 transfers L-fucose to Gal1,3GlcNAc

Stable Identifier
R-HSA-5693925
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen, Golgi membrane
ReviewStatus
5/5
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FUT3 transfers L-fucose to Gal1,3GlcNAc
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Human galactoside 3(4)-L-fucosyltransferase (FUT3) may be involved in Lewis blood group (Le) determination. Le+ individuals have an active enzyme while Le- individuals have an inactive enzyme. FUT3 catalyses alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Le blood groups. The 1,3-galactosyl derivative is shown here (Cameron et al. 1995).
Literature References
PubMed ID Title Journal Year
7650030 Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms

Szczepaniak, D, Weston, BW, Cameron, HS

J. Biol. Chem. 1995
Participants
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Output
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as an event of
Catalyst Activity

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity of FUT3 [Golgi membrane]

Physical Entity
FUT3 [Golgi membrane] (Homo sapiens)
Activity
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity (GO:0017060)
Orthologous Events
FUT3 transfers L-fucose to Gal1,3GlcNAc (Bos taurus)
FUT3 transfers L-fucose to Gal1,3GlcNAc (Caenorhabditis elegans)
FUT3 transfers L-fucose to Gal1,3GlcNAc (Canis familiaris)
FUT3 transfers L-fucose to Gal1,3GlcNAc (Dictyostelium discoideum)
FUT3 transfers L-fucose to Gal1,3GlcNAc (Drosophila melanogaster)
FUT3 transfers L-fucose to Gal1,3GlcNAc (Sus scrofa)
FUT3 transfers L-fucose to Gal1,3GlcNAc (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-19)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-19)
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