FUT3 transfers L-fucose to Gal1,3GlcNAc

Stable Identifier
R-HSA-5693925
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Human galactoside 3(4)-L-fucosyltransferase (FUT3) may be involved in Lewis blood group (Le) determination. Le+ individuals have an active enzyme while Le- individuals have an inactive enzyme. FUT3 catalyses alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Le blood groups. The 1,3-galactosyl derivative is shown here (Cameron et al. 1995).

Literature References
PubMed ID Title Journal Year
7650030 Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms

Cameron, HS, Szczepaniak, D, Weston, BW

J. Biol. Chem. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity of FUT3 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created