Reactome | ADORA3 [plasma membrane]

ADORA3 [plasma membrane]

Stable Identifier

R-HSA-5693919

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenosine receptor A3, AA3R_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        Adenosine P1 receptors (Homo sapiens)
        
        A1 and A3 receptors bind adenosine (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)
        
        ADORA1,3:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA1,3 [plasma membrane] (Homo sapiens)
        
        ADORA3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0DMS8 ADORA3

Gene Names

ADORA3

Chain

chain:1-318

Reference Genes

BioGPS Gene:140 ADORA3

COSMIC (genes):ADORA3 ADORA3

CTD Gene:140 ADORA3

dbSNP Gene:140 ADORA3

ENSEMBL:ENSG00000282608 ADORA3

HGNC:268 ADORA3

KEGG:hsa:140 ADORA3

Monarch:140 ADORA3

NCBI Gene:140 ADORA3

OMIM:600445 ADORA3

UCSC:P0DMS8 ADORA3

Reference Transcript

RefSeq:NM_000677.3 ADORA3

Other Identifiers

11726823_at

140

206171_PM_at

206171_at

2428000

2428001

2428002

2428003

2428004

2428006

2428007

2428008

2428009

36255_at

A_23_P137931

GE79503

GO:0001609

GO:0001973

GO:0004930

GO:0005886

GO:0006355

GO:0006954

GO:0007165

GO:0007186

GO:0007190

GO:0008016

GO:0008285

GO:0009611

GO:0014061

GO:0016020

GO:0030336

GO:0030425

GO:0032088

GO:0042734

GO:0045202

GO:0060089

GO:0098685

GO:0099171

HMNXSV003018257

ILMN_1730710

L77730_at

PH_hs_0000033

PH_hs_0031122

g6031156_3p_at

Participates

as a member of

ADORA1,3 [plasma membrane] (Homo sapiens)

Inferred To

ADORA3 [plasma membrane] (Bos taurus)

ADORA3 [plasma membrane] (Caenorhabditis elegans)

ADORA3 [plasma membrane] (Canis familiaris)

ADORA3 [plasma membrane] (Gallus gallus)

TMIGD3 [plasma membrane] (Sus scrofa)

gtr-1 [plasma membrane] (Caenorhabditis elegans)

Homologues of ADORA3 [plasma membrane] (Caenorhabditis elegans)

Adora3 [plasma membrane] (Mus musculus)

Adora3 [plasma membrane] (Rattus norvegicus)

AdoR [plasma membrane] (Drosophila melanogaster)

ador-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000668.1

Guide to Pharmacology - Targets

ENSEMBL

ENST00000241356, ENSP00000241356, ENSG00000282608

OpenTargets

ENSG00000282608

ZINC - FDA approved

AA3R_HUMAN

ZINC - Substances

AA3R_HUMAN

ZINC - Biogenic

AA3R_HUMAN

ZINC target

P0DMS8

PRO

P0DMS8

GlyGen

P0DMS8

PDB

8X16, 8X17

ZINC - Investigational

AA3R_HUMAN

ZINC - Metabolites

AA3R_HUMAN

GeneCards

ADORA3

HPA

ENSG00000282608-ADORA3

Pharos - Targets

P0DMS8

ZINC - Predictions - Purchasable

AA3R_HUMAN