Reactome | FAAH2 hydrolyses AEA to AA and ETA

FAAH2 hydrolyses AEA to AA and ETA

Stable Identifier

R-HSA-5693751

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lipid droplet

Synonyms

H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Fatty acid amides are a class of lipid transmitters that include the endogenous cannabinoid anandamide (AEA) and the sleep-inducing chemical oleamide. The magnitude and duration of their signalling are controlled by enzymatic hydrolysis mediated by fatty-acid amide hydrolases 1 and 2 (FAAH, H2). Hydrolysis of AEA is described here (Wei et al. 2006). FAAH is localised to the ER membrane whereas FAAH2 is localised to lipid droplets (Kaczocha et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
17015445	A second fatty acid amide hydrolase with variable distribution among placental mammals Wei, BQ, Mikkelsen, TS, McKinney, MK, Lander, ES, Cravatt, BF	J. Biol. Chem.	2006
19926788	Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2 Kaczocha, M, Glaser, ST, Chae, J, Brown, DA, Deutsch, DG	J. Biol. Chem.	2010