Reactome | FAAH hydrolyses AEA to AA and ETA

FAAH hydrolyses AEA to AA and ETA

Stable Identifier

R-HSA-5693742

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine

ReviewStatus

5/5

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Fatty acid amides are a class of lipid transmitters that include the endogenous cannabinoid anandamide (AEA) and the sleep-inducing chemical oleamide. The magnitude and duration of their signalling are controlled by enzymatic hydrolysis mediated by fatty-acid amide hydrolases 1 and 2 (FAAH, H2). Hydrolysis of AEA is described here (Wei et al. 2006). FAAH is localised to the ER membrane whereas FAAH2 is localised to lipid droplets (Kaczocha et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
17015445	A second fatty acid amide hydrolase with variable distribution among placental mammals Cravatt, BF, Wei, BQ, Lander, ES, McKinney, MK, Mikkelsen, TS	J. Biol. Chem.	2006
19926788	Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2 Deutsch, DG, Glaser, ST, Brown, DA, Chae, J, Kaczocha, M	J. Biol. Chem.	2010