FAAH hydrolyses AEA to AA and ETA

Stable Identifier
R-HSA-5693742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Fatty acid amides are a class of lipid transmitters that include the endogenous cannabinoid anandamide (AEA) and the sleep-inducing chemical oleamide. The magnitude and duration of their signalling are controlled by enzymatic hydrolysis mediated by fatty-acid amide hydrolases 1 and 2 (FAAH, H2). Hydrolysis of AEA is described here (Wei et al. 2006). FAAH is localised to the ER membrane whereas FAAH2 is localised to lipid droplets (Kaczocha et al. 2010).

Literature References
PubMed ID Title Journal Year
19926788 Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2

Kaczocha, M, Glaser, ST, Chae, J, Brown, DA, Deutsch, DG

J. Biol. Chem. 2010
17015445 A second fatty acid amide hydrolase with variable distribution among placental mammals

Wei, BQ, Mikkelsen, TS, McKinney, MK, Lander, ES, Cravatt, BF

J. Biol. Chem. 2006
Participants
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Catalyst Activity
Catalyst Activity
Title
fatty acid amide hydrolase activity of FAAH [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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