S-formylglutathione hydrolase (ESD, esterase D) is a homodimeric enzyme in the ER lumen of red blood cells that can hydrolyse S-formylglutathione (S-FGSH) to glutathione (GSH) and formate (Hopkinson et al. 1973, Eiberg & Mohr 1986). It is also able to hydrolyse 4-methylumbelliferyl acetate (not shown here).
Mestriner, MA, Hopkinson, DA, Harris, H, Cortner, J
Mohr, J, Eiberg, H
S-formylglutathione hydrolase activity of ESD dimer [endoplasmic reticulum lumen]
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