ESD dimer hydrolyses S-FGSH to GSH

Stable Identifier
R-HSA-5693724
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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ESD dimer hydrolyses S-FGSH to GSH
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S-formylglutathione hydrolase (ESD, esterase D) is a homodimeric enzyme in the ER lumen of red blood cells that can hydrolyse S-formylglutathione (S-FGSH) to glutathione (GSH) and formate (Hopkinson et al. 1973, Eiberg & Mohr 1986). It is also able to hydrolyse 4-methylumbelliferyl acetate (not shown here).
Literature References
PubMed ID Title Journal Year
4768551 Esterase D: a new human polymorphism

Hopkinson, DA, Mestriner, MA, Cortner, J, Harris, H

Ann. Hum. Genet. 1973
3770744 Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells

Eiberg, H, Mohr, J

Hum. Genet. 1986
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Catalyst Activity

S-formylglutathione hydrolase activity of ESD dimer [endoplasmic reticulum lumen]

Physical Entity
ESD dimer [endoplasmic reticulum lumen] (Homo sapiens)
Activity
S-formylglutathione hydrolase activity (GO:0018738)
Orthologous Events
ESD dimer hydrolyses S-FGSH to GSH (Bos taurus)
ESD dimer hydrolyses S-FGSH to GSH (Caenorhabditis elegans)
ESD dimer hydrolyses S-FGSH to GSH (Canis familiaris)
ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)
ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)
ESD dimer hydrolyses S-FGSH to GSH (Drosophila melanogaster)
ESD dimer hydrolyses S-FGSH to GSH (Gallus gallus)
ESD dimer hydrolyses S-FGSH to GSH (Mus musculus)
ESD dimer hydrolyses S-FGSH to GSH (Rattus norvegicus)
ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)
ESD dimer hydrolyses S-FGSH to GSH (Sus scrofa)
ESD dimer hydrolyses S-FGSH to GSH (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2015-05-18)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-18)
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