Reactome | ESD dimer hydrolyses S-FGSH to GSH

ESD dimer hydrolyses S-FGSH to GSH

Stable Identifier

R-HSA-5693724

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

S-formylglutathione hydrolase (ESD, esterase D) is a homodimeric enzyme in the ER lumen of red blood cells that can hydrolyse S-formylglutathione (S-FGSH) to glutathione (GSH) and formate (Hopkinson et al. 1973, Eiberg & Mohr 1986). It is also able to hydrolyse 4-methylumbelliferyl acetate (not shown here).

Literature References

PubMed ID	Title	Journal	Year
3770744	Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells Eiberg, H, Mohr, J	Hum. Genet.	1986
4768551	Esterase D: a new human polymorphism Hopkinson, DA, Mestriner, MA, Cortner, J, Harris, H	Ann. Hum. Genet.	1973