HOXB1 maintains activation of HOXB1 chromatin

Stable Identifier
R-HSA-5693644
Type
Reaction [omitted]
Species
Homo sapiens
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As inferred from mouse embryos and embryonal carcinoma cells, HOXB1 binds with the PBX1:PKNOX1 (PBX1:PREP1) heterodimer (Berthelsen et al. 1998) and MEIS1at the promoter of the HOXB1 gene to maintain expression after initial activation of HOXB1 by retinoic acid signaling. Binding of SOX:OCT heterodimers to the mouse HOXB1 promoter also appear to positively regulate HOXB1 transcription.

Literature References
PubMed ID Title Journal Year
9482740 The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity

Berthelsen, J, Zappavigna, V, Ferretti, E, Mavilio, F, Blasi, F

EMBO J. 1998
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