Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis

Stable Identifier
R-HSA-5693615
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis
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DNA-PKcs (PRKDC) is recruited to the Ku70:Ku80:DNA double strand break ends complex (XRCC5:XRCC6:DNA DSBs) (Gottlieb and Jackson, 1993), causing Ku to translocate inwards (away from the break) approximately 10 bp (Yoo and Dynan, 1999). This forms the DNA-PK complex (DNA-PKcs plus Ku70/Ku80) at each end of the DSB. Two DNA-PK complexes, one on either side of the DSB, interact to bring the DNA ends together.

Literature References
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Input
Output
Participates
as an event of
Orthologous Events
Interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB (Gallus gallus)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Bos taurus)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Canis familiaris)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Danio rerio)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Dictyostelium discoideum)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Gallus gallus)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Mus musculus)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Rattus norvegicus)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Sus scrofa)
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Xenopus tropicalis)
Authored
Matthews, L  (2003-09-07)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-05-16)
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