MRN complex bound to DNA ends recruits ATM

Stable Identifier
R-HSA-5693612
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activation of ATM kinase in response to DNA damage in the form of DNA double strand breaks (DSBs) requires association of ATM dimers with the MRN complex bound to DNA ends. MRN subunit RAD50 is essential for ATM dimer binding (Lee and Paull 2005, Wu et al. 2007). ATM dimer exists in a preformed complex with KAT5 (Tip60) histone acetyltransferase (Sun et al. 2005).

Literature References
PubMed ID Title Journal Year
15790808 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Lee, JH, Paull, TT

Science 2005
16141325 A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y, Jiang, X, Chen, S, Fernandes, N, Price, BD

Proc. Natl. Acad. Sci. U.S.A. 2005
17694070 MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

Wu, Y, Xiao, S, Zhu, XD

Nat. Struct. Mol. Biol. 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created