Reactome | MRN complex bound to DNA ends recruits ATM

MRN complex bound to DNA ends recruits ATM

Stable Identifier

R-HSA-5693612

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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MRN complex bound to DNA ends recruits ATM

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Activation of ATM kinase in response to DNA damage in the form of DNA double strand breaks (DSBs) requires association of ATM dimers with the MRN complex bound to DNA ends. MRN subunit RAD50 is essential for ATM dimer binding (Lee and Paull 2005, Wu et al. 2007). ATM dimer exists in a preformed complex with KAT5 (Tip60) histone acetyltransferase (Sun et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15790808	ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex Lee, JH, Paull, TT	Science	2005
16141325	A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM Sun, Y, Jiang, X, Chen, S, Fernandes, N, Price, BD	Proc. Natl. Acad. Sci. U.S.A.	2005
17694070	MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control Wu, Y, Xiao, S, Zhu, XD	Nat. Struct. Mol. Biol.	2007