Reactome | TP53BP1 associates with H4K20Me2 at DNA DSBs

TP53BP1 associates with H4K20Me2 at DNA DSBs

Stable Identifier

R-HSA-5693566

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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TP53BP1 associates with H4K20Me2 at DNA DSBs

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RNF8- and RNF168-mediated removal of KDM4A and KDM4B from H4K20Me2 (Me2-K21-HIST1H4A) enables TP53BP1 (53BP1) recruitment to WHSC1-methylated histone H4K20Me2 at DNA double strand breaks (DSBs) (Pei et al. 2011, Mallette et al. 2012)

Literature References

PubMed ID	Title	Journal	Year
21293379	MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites Pei, H, Zhang, L, Luo, K, Qin, Y, Chesi, M, Fei, F, Bergsagel, PL, Wang, L, You, Z, Lou, Z	Nature	2011
22373579	RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites Mallette, FA, Mattiroli, F, Cui, G, Young, LC, Hendzel, MJ, Mer, G, Sixma, TK, Richard, S	EMBO J.	2012