TP53BP1 associates with H4K20Me2 at DNA DSBs

Stable Identifier
R-HSA-5693566
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RNF8- and RNF168-mediated removal of KDM4A and KDM4B from H4K20Me2 (Me2-K21-HIST1H4A) enables TP53BP1 (53BP1) recruitment to WHSC1-methylated histone H4K20Me2 at DNA double strand breaks (DSBs) (Pei et al. 2011, Mallette et al. 2012)

Literature References
PubMed ID Title Journal Year
21293379 MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Pei, H, Zhang, L, Luo, K, Qin, Y, Chesi, M, Fei, F, Bergsagel, PL, Wang, L, You, Z, Lou, Z

Nature 2011
22373579 RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Mallette, FA, Mattiroli, F, Cui, G, Young, LC, Hendzel, MJ, Mer, G, Sixma, TK, Richard, S

EMBO J. 2012
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