Reactome | Association of RAD51 with RAD52:DNA double-strand break ends

Association of RAD51 with RAD52:DNA double-strand break ends

Stable Identifier

R-HSA-5693564

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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Association of RAD51 with RAD52:DNA double-strand break ends

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RAD52 can simultaneously interact with RAD51 and RPA. The interaction with RAD51 may inhibit the formation of the invading RAD51 filament by sequestering RAD51 from RPA, thus promoting single strand annealing (SSA) instead of homologous recombination (Chen et al. 1999, Stark et al. 2004, Singleton et al. 2002, Mansour et al. 2008). The interaction of RAD51 and RAD52 is promoted by ABL1-mediated phosphorylation of both RAD51 and RAD52 (Chen et al. 1999, Van Dyck et al. 1999), which also increases RAD52 affinity for DNA (Honda et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
15485900	Genetic steps of mammalian homologous repair with distinct mutagenic consequences Pierce, AJ, Jasin, M, Oh, J, Stark, JM, Pastink, A	Mol. Cell. Biol.	2004
18539610	Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks Haag, F, Borgmann, K, Schmidt-Petersen, F, Rhein, T, Mansour, WY, Rosskopf, R, Willers, H, Schumacher, S, Gatzemeier, F, Dahm-Daphi, J	Nucleic Acids Res.	2008
10438626	Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52. West, SC, Baumann, P	J Mol Biol	1999
10212258	Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl Cong, F, Baltimore, D, Goff, SP, Chen, G, Lee, EY, Gasser, PJ, Yuan, SS, Park, MS, Song, B, Arlinghaus, R, Wu, Y, Xu, Y, Trujillo, K, Sung, P, Liu, W	J Biol Chem	1999
9837724	Visualisation of human rad52 protein and its complexes with hRad51 and DNA. West, SC, Hajibagheri, NM, Stasiak, A, Van Dyck, E	J Mol Biol	1999
12370410	Structure of the single-strand annealing domain of human RAD52 protein. West, SC, Wentzell, LM, Wigley, DB, Liu, Y, Singleton, MR	Proc Natl Acad Sci U S A	2002
21804533	Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding Spies, M, Ha, T, Honda, M, Yoo, J, Okuno, Y	EMBO J.	2011