HSD17B11 dehydrogenates EST17b to E1

Stable Identifier
R-HSA-5693390
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HSD17B11 dehydrogenates EST17b to E1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) may participate in androgen metabolism during steroidogenesis where it dehydrogenates estradiol-17-beta (EST17b) to estrone (E1) (Chai et al. 2003).
Literature References
PubMed ID Title Journal Year
12697717 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells

Chai, Z, Brereton, P, Suzuki, T, Sasano, H, Obeyesekere, V, Escher, G, Saffery, R, Fuller, P, Enriquez, C, Krozowski, Z

Endocrinology 2003
Participants
Input
Output
Participates
as an event of
Event Information
Reverse Reaction
HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)
Catalyst Activity

estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B11 [cytosol]

Physical Entity
HSD17B11 [cytosol] (Homo sapiens)
Activity
estradiol 17-beta-dehydrogenase [NAD(P)+] activity (GO:0004303)
Orthologous Events
HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)
HSD17B11 dehydrogenates EST17b to E1 (Caenorhabditis elegans)
HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)
HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)
HSD17B11 dehydrogenates EST17b to E1 (Gallus gallus)
HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)
HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)
HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)
HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)
HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2015-05-15)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-15)
Cite Us!