Reactome | DDAH1 hydrolyses ADMA to DMA and L-Cit

DDAH1 hydrolyses ADMA to DMA and L-Cit

Stable Identifier

R-HSA-5693373

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Synonyms

H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline

ReviewStatus

5/5

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N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1) plays a role in the regulation of nitric oxide generation by catalyzing the hydrolysis an endogenous inhibitor of nitric oxide synthase (NOS), N(omega),N(omega)-dimethyl-L-arginine (ADMA) to dimethylamine (DMA) and L-citrulline (L-Cit) (Forbes et al. 2008, Wang et al. 2009). DDAH2, an isoform of DDAH1 previously thought to catalyze this reaction (Cillero-Pastor et al. 2012) has recently been shown to have no detectable catalytic activity against ADMA under conditions in which DDAH1 is active (Ragavan et al. 2023).

Literature References

PubMed ID	Title	Journal	Year
37296100	A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase Rubets, E, Jarzebska, N, Suzuki-Yamamoto, T, Chen, Y, Bernhardt, N, Bianconi, E, Macchiarulo, A, Mukhopadhyay, D, Mangoni, AA, Wang, Y, Ruta, L, Tommasi, S, Chau, S, Grottelli, S, Tararova, ND, Ragavan, VN, Spieth, PM, Ryazanskiy, D, Weiss, N, Kimoto, M, Cellini, B, Martens-Lobenhoffer, J, Bornstein, SR, Bode-Böger, SM, Angom, RS, Maas, R, Nair, PC, Hu, X, Rodionov, RN, Lentz, SR	Nat Commun	2023
21898353	Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes Oreiro, N, Ruiz-Romero, C, Mateos, J, Blanco, FJ, Cillero-Pastor, B, Fernández-López, C	Arthritis Rheum.	2012
19663506	Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide Monzingo, AF, Robertus, JD, Wang, Y, Fast, W, Schaller, TH, Hu, S	Biochemistry	2009
18171027	Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation Green-Church, KB, Forbes, SP, Guzman, JE, Parinandi, N, Druhan, LJ, Cardounel, AJ, Zhang, L	Biochemistry	2008