DDAH1,2 hydrolyses ADMA to DMA and L-Cit

Stable Identifier
R-HSA-5693373
Type
Reaction
Species
Homo sapiens
Compartment
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N(G),N(G)-dimethylarginine dimethylaminohydrolases 1 and 2 (DDAH1 and 2) play a role in the regulation of nitric oxide generation. They can hydrolyse an endogenous inhibitor of nitric oxide synthase (NOS), N(omega),N(omega)-dimethyl-L-arginine (ADMA) to dimethylamine (DMA) and L-citrulline (L-Cit) (Forbes et al. 2008, Wang et al. 2009, Cillero-Pastor et al. 2012).

Literature References
PubMed ID Title Journal Year
21898353 Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes

Oreiro, N, Ruiz-Romero, C, Mateos, J, Blanco, FJ, Cillero-Pastor, B, Fernández-López, C

Arthritis Rheum. 2012
19663506 Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide

Monzingo, AF, Robertus, JD, Wang, Y, Fast, W, Schaller, TH, Hu, S

Biochemistry 2009
18171027 Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation

Green-Church, KB, Forbes, SP, Guzman, JE, Parinandi, N, Druhan, LJ, Cardounel, AJ, Zhang, L

Biochemistry 2008
Participants
Participates
Catalyst Activity

dimethylargininase activity of DDAH1,2 [cytosol]

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