BACE1 translocates from ER lumen to Golgi apparatus

Stable Identifier
R-HSA-5693071
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, plasma membrane
ReviewStatus
5/5
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BACE1 translocates from ER lumen to Golgi apparatus
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Beta secretase 1 (BACE1) is acetylated on 7 lysine residues inthe ER lumen (7K-BACE1). This protects the nascent protein from degradation in the ER Golgi intermediate compartment (ERGIC) and allows it to reach the Golgi apparatus (Kandalepas & Vassar 2014). The mechanism of this translocation is unknown.

Literature References
PubMed ID Title Journal Year
24893886 The normal and pathologic roles of the Alzheimer's β-secretase, BACE1

Kandalepas, PC, Vassar, R

Curr Alzheimer Res 2014
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Authored
Jassal, B  (2015-05-13)
Reviewed
D'Eustachio, P  (2015-06-26)
Perry, G  (2015-11-09)
Created
Jassal, B  (2015-05-13)
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