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BACE1 translocates from ER lumen to Golgi apparatus
Stable Identifier
R-HSA-5693071
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
BACE1 translocates from ER lumen to Golgi apparatus (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Beta secretase 1 (BACE1) is acetylated on 7 lysine residues inthe ER lumen (7K-BACE1). This protects the nascent protein from degradation in the ER Golgi intermediate compartment (ERGIC) and allows it to reach the Golgi apparatus (Kandalepas & Vassar 2014). The mechanism of this translocation is unknown.
Literature References
PubMed ID
Title
Journal
Year
24893886
The normal and pathologic roles of the Alzheimer's β-secretase, BACE1
Kandalepas, PC
,
Vassar, R
Curr Alzheimer Res
2014
Participants
Input
7K-BACE1 [endoplasmic reticulum lumen]
(Homo sapiens)
Output
7K-BACE1 [Golgi-associated vesicle lumen]
(Homo sapiens)
Participates
as an event of
Amyloid fiber formation (Homo sapiens)
Authored
Jassal, B (2015-05-13)
Reviewed
D'Eustachio, P (2015-06-26)
Perry, G (2015-11-09)
Created
Jassal, B (2015-05-13)
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