NAT8,8B acetylate BACE1

Stable Identifier
R-HSA-5693001
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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NAT8,8B acetylate BACE1
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N-acetyltransferase 8 and 8B (NAT8, 8B) can mediate the molecular stabilisation of BACE1, the membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer disease amyloid beta-peptide. Specifically, nascent BACE1 is transiently acetylated on seven lysine residues in the ER lumen which protects the nascent protein from degradation in the ER Golgi intermediate compartment (ERGIC) and allows it to reach the Golgi apparatus (Ko & Puglielli 2009, Costantini et al. 2007). Lysine-acetylated BACE1 (7K-BACE1) is deacetylated in the Golgi apparatus.
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Catalyst Activity

L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor of NAT8, 8B [endoplasmic reticulum membrane]

Physical Entity
NAT8, 8B [endoplasmic reticulum membrane] (Homo sapiens)
Activity
L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor (GO:0004468)
Authored
Jassal, B  (2015-05-13)
Reviewed
D'Eustachio, P  (2015-06-26)
Perry, G  (2015-11-09)
Created
Jassal, B  (2015-05-13)
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