BACE1:GGA1,2,3 translocates from plasma membrane to endosome

Stable Identifier
R-HSA-5692941
Type
Reaction [dissociation]
Species
Homo sapiens
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Beta-secretase 1 (BACE1, memapsin-2) mediates the proteolytic processing of amyloid precursor protein (APP). BACE1 is transported from the cell surface to endosomes where APP hydrolysis takes place. The acid-cluster-dileucine (ACDL) motif in the cytosolic domain of BACE1 is able to bind to the VHS domain of ADP-ribosylation factor-binding proteins 1, 2 and 3 (GGA1,2,3) which play a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. This is the presumed recognition step for BACE1 transport to endosomes (He et al. 2003).

Literature References
PubMed ID Title Journal Year
14567678 Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

He, X, Zhu, G, Koelsch, G, Rodgers, KK, Zhang, XC, Tang, J

Biochemistry 2003
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