p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN

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R-HSA-5692781
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Reaction [binding]
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Homo sapiens
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MAPK6 and MAPKAPK5 bind to the GDP-exchange factor KALRN, also known as Kalirin-7 or KAL7 (Brand et al, 2012). CaMKII-dependent phosphorylation of KALRN7 results in activation of PAK kinases in dendritic spines, potentially establishing a positive feedback loop that governs the MAPK6:MAPKAPK5 module in neuronal developement (Penzes et al, 2003; Xie et al, 2007).

Literature References
PubMed ID Title Journal Year
18031682 Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines

Penzes, P, Kai, L, Surmeier, DJ, Photowala, H, Cahill, ME, Srivastava, DP, Woolfrey, KM, Xie, Z, Shum, CY

Neuron 2007
12546821 Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

Penzes, P, Eipper, BA, Schiller, MR, Huganir, RL, Chernoff, J, Beeser, A, Mains, RE

Neuron 2003
22508986 The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

Schumacher, S, Brand, F, Kant, S, Meloche, S, Kotlyarov, A, Gaestel, M, Menon, MB, Turgeon, B, Simon, R, Britsch, S

Mol. Cell. Biol. 2012
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