SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5

Stable Identifier
Reaction [binding]
Homo sapiens
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SEPT7 forms a ternary complex with MAPK6 and MAPKAPK5 that contributes to neuronal development through the phosphorylation of the Binders of RHO GTPase (BORG) proteins (Brand et al, 2012). Septins are cytoskeletal GTP-binding proteins that form filaments and contribute to processes such as cytokinesis, cell polarity and cell division, among others (reviewed in Spiliotis and Nelson, 2006). Interaction of septin proteins with the CDC42 effector proteins 2, 3 and 5 (CDC42EP2, 3, 5; also known as BORG1, 2 and 3) inhibits formation of septin filaments (Jouberty et al, 2001).

Literature References
PubMed ID Title Journal Year
11584266 Borg proteins control septin organization and are negatively regulated by Cdc42

Perlungher, RR, Joberty, G, Macara, IG, Kinoshita, M, Sheffield, PJ, Haystead, T, Noda, M

Nat. Cell Biol. 2001
16371649 Here come the septins: novel polymers that coordinate intracellular functions and organization

Spiliotis, ET, Nelson, WJ

J. Cell. Sci. 2006
22508986 The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

Schumacher, S, Brand, F, Kant, S, Meloche, S, Kotlyarov, A, Gaestel, M, Menon, MB, Turgeon, B, Simon, R, Britsch, S

Mol. Cell. Biol. 2012
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