Reactome | ANG binds F-actin

ANG binds F-actin

Stable Identifier

R-HSA-5692437

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Angiogenin (ANG) binds to F-actin on the surface of endothelial cells. Once bound, ANG is endocytosed and translocated to the nucleus where it stimulates ribosomal RNA syntheses which induce vascularisation of normal and malignant tissues (Dickson et al. 2009). Defects in ANG can cause amyotrophic lateral sclerosis 9 (ALS9; MIM:611895), a fatal progressive neurodegenerative disorder characterised by the preferential loss of motor neurons in the brain stem, motor cortex and spinal cord, resulting in paralysis and respiratory failure between 3 to 5 years of onset of symptoms (Padhi et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
19354288	Ribonuclease inhibitor regulates neovascularization by human angiogenin Dickson, KA, Kang, DK, Kwon, YS, Kim, JC, Leland, PA, Kim, BM, Chang, SI, Raines, RT	Biochemistry	2009
25372031	Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis Padhi, AK, Banerjee, K, Gomes, J, Banerjee, M	PLoS ONE	2014