ANG binds F-actin

Stable Identifier
R-HSA-5692437
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Angiogenin (ANG) binds to F-actin on the surface of endothelial cells. Once bound, ANG is endocytosed and translocated to the nucleus where it stimulates ribosomal RNA syntheses which induce vascularisation of normal and malignant tissues (Dickson et al. 2009). Defects in ANG can cause amyotrophic lateral sclerosis 9 (ALS9; MIM:611895), a fatal progressive neurodegenerative disorder characterised by the preferential loss of motor neurons in the brain stem, motor cortex and spinal cord, resulting in paralysis and respiratory failure between 3 to 5 years of onset of symptoms (Padhi et al. 2014).

Literature References
PubMed ID Title Journal Year
25372031 Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis

Padhi, AK, Banerjee, K, Gomes, J, Banerjee, M

PLoS ONE 2014
19354288 Ribonuclease inhibitor regulates neovascularization by human angiogenin

Dickson, KA, Kang, DK, Kwon, YS, Kim, JC, Leland, PA, Kim, BM, Chang, SI, Raines, RT

Biochemistry 2009
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