NPR2 binds NPPC

Stable Identifier
R-HSA-5692408
Type
Reaction [binding]
Species
Homo sapiens
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Atrial natriuretic peptide receptor 2 (NPR2) binds the C-type natriuretic peptide (NPPC, CNP) hormone. Natriuretic peptide hormones can stimulate natriuretic, diuretic, and vasorelaxant activity through the activation of guanylyl cyclases (Koller et al. 1991, Bartels et al. 2004).

Literature References
PubMed ID Title Journal Year
1672777 Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)

Koller, KJ, Lowe, DG, Bennett, GL, Minamino, N, Kangawa, K, Matsuo, H, Goeddel, DV

Science 1991
15146390 Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux

Bartels, CF, Bükülmez, H, Padayatti, P, Rhee, DK, van Ravenswaaij-Arts, C, Pauli, RM, Mundlos, S, Chitayat, D, Shih, LY, Al-Gazali, LI, Kant, S, Cole, T, Morton, J, Cormier-Daire, V, Faivre, L, Lees, M, Kirk, J, Mortier, GR, Leroy, J, Zabel, B, Kim, CA, Crow, Y, Braverman, NE, van den Akker, F, Warman, ML

Am. J. Hum. Genet. 2004
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