NPR2 binds NPPC

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Atrial natriuretic peptide receptor 2 (NPR2) binds the C-type natriuretic peptide (NPPC, CNP) hormone. Natriuretic peptide hormones can stimulate natriuretic, diuretic, and vasorelaxant activity through the activation of guanylyl cyclases (Koller et al. 1991, Bartels et al. 2004).

Literature References
PubMed ID Title Journal Year
15146390 Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux

Kim, CA, Kirk, J, Mortier, GR, Faivre, L, Lees, M, Kant, S, Bartels, CF, van Ravenswaaij-Arts, C, Padayatti, P, Shih, LY, Bükülmez, H, Leroy, J, Morton, J, Braverman, NE, Al-Gazali, LI, Crow, Y, Warman, ML, Chitayat, D, van den Akker, F, Cole, T, Pauli, RM, Mundlos, S, Zabel, B, Cormier-Daire, V, Rhee, DK

Am. J. Hum. Genet. 2004
1672777 Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)

Lowe, DG, Kangawa, K, Bennett, GL, Koller, KJ, Matsuo, H, Goeddel, DV, Minamino, N

Science 1991
Orthologous Events
Cite Us!