Reactome | ADH5 [cytosol]

ADH5 [cytosol]

Stable Identifier

R-HSA-5692235

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alcohol dehydrogenase class-3 ecNumber1.1.1.1/ecNumber, ADHX_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Ethanol oxidation (Homo sapiens)
      - ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)
        
        ADH5:2xZn2+ dimer [cytosol] (Homo sapiens)
        
        ADH5:2xZn2+ [cytosol] (Homo sapiens)
        
        ADH5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11766 ADH5

Gene Names

ADH5, ADHX, FDH

Chain

initiator methionine:1, chain:2-374

Reference Genes

BioGPS Gene:128 ADH5

COSMIC (genes):ADH5 ADH5

CTD Gene:128 ADH5

dbSNP Gene:128 ADH5

ENSEMBL:ENSG00000197894 ADH5

HGNC:253 ADH5

KEGG Gene (Homo sapiens):128 ADH5

Monarch:128 ADH5

NCBI Gene:128 ADH5

OMIM:103710 ADH5

Reference Transcript

RefSeq:NM_000671.4 ADH5

Other Identifiers

0001410403

11716392_s_at

11716393_x_at

11716394_x_at

128

208847_s_at

208848_at

2343643

237121_at

2387765

2387768

2412720

2779094

2779096

2779097

2779098

2779099

2779101

2779104

2779107

2779108

2779111

2779112

2779113

2779114

2779117

2779119

2959649

37707_i_at

37708_r_at

60901_at

8101844

A_23_P18692

A_24_P260346

A_32_P198399

GE60516

GE851357

GO:0001523

GO:0003013

GO:0003016

GO:0003674

GO:0004022

GO:0004024

GO:0005504

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005739

GO:0005829

GO:0006069

GO:0006091

GO:0006464

GO:0006629

GO:0006950

GO:0008150

GO:0008270

GO:0008289

GO:0009055

GO:0009056

GO:0010430

GO:0016491

GO:0018119

GO:0018467

GO:0022900

GO:0032496

GO:0042802

GO:0043167

GO:0043226

GO:0044281

GO:0045777

GO:0046294

GO:0046872

GO:0051409

GO:0051775

GO:0051903

GO:0055114

GO:0070062

Hs.61993.0.A1_3p_at

ILMN_1738604

M81118_at

PH_hs_0028993

TC04001405.hg

g178131_3p_a_at

g178133_3p_at

Participant Of

hasComponent

ADH5:2xZn2+ [cytosol]

Inferred To

ADH5 [cytosol] (Bos taurus)

ADH5 [cytosol] (Caenorhabditis elegans)

ADH5 [cytosol] (Canis familiaris)

ADH5 [cytosol] (Gallus gallus)

ADH5 [cytosol] (Schizosaccharomyces pombe)

ADH5 [cytosol] (Sus scrofa)

ADH5 [cytosol] (Xenopus tropicalis)

adh5 [cytosol] (Danio rerio)

adh5 [cytosol] (Dictyostelium discoideum)

SFA1 [cytosol] (Saccharomyces cerevisiae)

Adh5 [cytosol] (Mus musculus)

Adh5 [cytosol] (Rattus norvegicus)

Homologues of ADH5 [cytosol] (Canis familiaris)

Fdh [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_000662.3

OpenTargets

ENSG00000197894

IntEnz

1.1.1.284

GeneCards

P11766

HPA

ENSG00000197894-ADH5

Ensembl

ENST00000296412, ENSP00000296412, ENSG00000197894

PRO

P11766

HMDB Protein

HMDBP00780

PDB

3QJ5, 1MA0, 2FZW, 1MC5, 2FZE, 1M6H, 1MP0, 1M6W, 1TEH