BRISC complex deubiquitinates NLRP3

Stable Identifier
R-HSA-5691439
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As part of the cytosolic BRISC complex (Cooper et al. 2009), BRCC3 regulates NLRP3 activity by promoting K63-deubiquitination of its LRR domain (Py et al. 2013). The consequent activation of NLRP3 has been proposed to mediate necrotic cell sensing and the subsequent release of the proinflammatory cytokine IL-1Beta after hypoxic injury (Iyer et al. 2009).

Literature References
PubMed ID Title Journal Year
23246432 Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity

Py, BF, Kim, MS, Vakifahmetoglu-Norberg, H, Yuan, J

Mol. Cell 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of BRISC complex:K63polyUb-NLRP3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created