MYSM1 deubiquitinates Histone H2A

Stable Identifier
R-HSA-5691381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MYSM1 is required for full activation of several transcriptional events, including androgen receptor (AR)-regulated target genes in prostate cancer cells. It is part of a regulatory protein complex with the histone acetyltransferase EP300 (p300) and KAT2B (CBP-associated factor (p/CAF)), regulating transcriptional initiation and elongaion by coordinating histone acetylation, H2A deubiquitination and linker histone dissociation. MYSM1 preferentially deubiquitinates H2A in hyperacetylated nucleosomes (Zhu et al. 2007).

Literature References
PubMed ID Title Journal Year
17707232 A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation

Zhu, P, Zhou, W, Wang, J, Puc, J, Ohgi, KA, Erdjument-Bromage, H, Tempst, P, Glass, CK, Rosenfeld, MG

Mol. Cell 2007
Participants
Participates
Catalyst Activity

thiol-dependent ubiquitin-specific protease activity of MYSM1:EP300:KAT2B:Ub-histone H2A [nucleoplasm]

Orthologous Events
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