MYSM1 is required for full activation of several transcriptional events, including androgen receptor (AR)-regulated target genes in prostate cancer cells. It is part of a regulatory protein complex with the histone acetyltransferase EP300 (p300) and KAT2B (CBP-associated factor (p/CAF)), regulating transcriptional initiation and elongaion by coordinating histone acetylation, H2A deubiquitination and linker histone dissociation. MYSM1 preferentially deubiquitinates H2A in hyperacetylated nucleosomes (Zhu et al. 2007).
Zhu, P, Zhou, W, Wang, J, Puc, J, Ohgi, KA, Erdjument-Bromage, H, Tempst, P, Glass, CK, Rosenfeld, MG
thiol-dependent ubiquitin-specific protease activity of MYSM1:EP300:KAT2B:Ub-histone H2A [nucleoplasm]
© 2021 Reactome
