Reactome | HFE binds TFRC dimer

HFE binds TFRC dimer

Stable Identifier

R-HSA-5691154

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Transferrin, in dimeric form (TFRC dimer), mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. Hereditary hemochromatosis protein (HFE) binds to TFRC dimer and reduces its affinity for iron-loaded transferrin (Feder et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9465039	The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding Schatzman, RC, Tsuchihashi, Z, Bjorkman, PJ, Sigal, E, Penny, DM, Lebrón, JA, Irrinki, A, Feder, JN, Watson, N, Lee, VK	Proc. Natl. Acad. Sci. U.S.A.	1998