Transferrin, in dimeric form (TFRC dimer), mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. Hereditary hemochromatosis protein (HFE) binds to TFRC dimer and reduces its affinity for iron-loaded transferrin (Feder et al. 1998).
Feder, JN, Penny, DM, Irrinki, A, Lee, VK, Lebrón, JA, Watson, N, Tsuchihashi, Z, Sigal, E, Bjorkman, PJ, Schatzman, RC
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