HFE binds TFRC dimer

Stable Identifier
R-HSA-5691154
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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HFE binds TFRC dimer
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Transferrin, in dimeric form (TFRC dimer), mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. Hereditary hemochromatosis protein (HFE) binds to TFRC dimer and reduces its affinity for iron-loaded transferrin (Feder et al. 1998).

Literature References
PubMed ID Title Journal Year
9465039 The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

Feder, JN, Penny, DM, Irrinki, A, Lee, VK, Lebrón, JA, Watson, N, Tsuchihashi, Z, Sigal, E, Bjorkman, PJ, Schatzman, RC

Proc. Natl. Acad. Sci. U.S.A. 1998
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Authored
Jassal, B  (2015-05-05)
Reviewed
D'Eustachio, P  (2017-01-11)
Created
Jassal, B  (2015-05-05)