Reactome | HFE binds TFRC dimer

HFE binds TFRC dimer

Stable Identifier

R-HSA-5691154

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Transferrin, in dimeric form (TFRC dimer), mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. Hereditary hemochromatosis protein (HFE) binds to TFRC dimer and reduces its affinity for iron-loaded transferrin (Feder et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9465039	The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding Feder, JN, Penny, DM, Irrinki, A, Lee, VK, Lebrón, JA, Watson, N, Tsuchihashi, Z, Sigal, E, Bjorkman, PJ, Schatzman, RC	Proc. Natl. Acad. Sci. U.S.A.	1998