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Ub-K-IREB2 [cytosol]
Stable Identifier
R-HSA-5691152
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Iron-responsive element-binding protein 2, IREB2_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)
Ub-K-IREB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48200 IREB2
Gene Names
IREB2
Chain
chain:1-963
Reference Genes
BioGPS Gene:3658 IREB2
COSMIC (genes):IREB2 IREB2
CTD Gene:3658 IREB2
dbSNP Gene:3658 IREB2
ENSEMBL:ENSG00000136381 IREB2
HGNC:6115 IREB2
KEGG:hsa:3658 IREB2
Monarch:3658 IREB2
NCBI Gene:3658 IREB2
OMIM:147582 IREB2
UCSC:P48200 IREB2
Reference Transcript
RefSeq:NM_001320943.1 IREB2
RefSeq:NM_004136.3 IREB2
RefSeq:NM_001320941.1 IREB2
Other Identifiers
11721363_x_at
11721364_s_at
11721365_a_at
11752798_a_at
11756521_a_at
11762719_at
1555476_PM_at
1555476_at
16803501
214666_PM_x_at
214666_x_at
225892_PM_at
225892_at
242261_PM_at
242261_at
3444509
3444545
3603335
3603337
3603338
3603339
3603341
3603348
3603349
3603350
3603351
3603352
3603355
3603356
3603357
3603358
3603359
3603360
3603361
3603362
3603363
3603364
3603365
3603366
3603367
3603368
3603369
3603370
3603371
3603372
3603373
3603374
3603375
3603376
3603377
3603378
3603379
3603380
3603381
3603382
3603384
3603385
3658
40345_at
4053677
54426_r_at
61344_at
63505_at
7985166
A_14_P133217
A_23_P106497
A_33_P3221528
GE58993
GO:0000900
GO:0002376
GO:0003723
GO:0003824
GO:0003994
GO:0005515
GO:0005737
GO:0005739
GO:0005829
GO:0006099
GO:0006101
GO:0006417
GO:0006782
GO:0006879
GO:0009791
GO:0010468
GO:0016829
GO:0017148
GO:0022600
GO:0030154
GO:0030316
GO:0030350
GO:0034101
GO:0043226
GO:0045182
GO:0046872
GO:0048255
GO:0050892
GO:0051536
GO:0051539
GO:0060586
HMNXSV003003049
Hs.295789.0.A1_3p_at
Hs.295789.0.A1_3p_x_at
Hs.295789.1.A1_3p_at
Hs.94149.0.S1_3p_at
Hs2.370324.1.S1_3p_at
ILMN_1726554
PH_hs_0017771
TC15000729.hg
TC15002301.hg
Participates
as an output of
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)
Other forms of this molecule
IREB2 [cytosol]
Inferred To
Homologues of Ub-K-IREB2 [cytosol]
(Drosophila melanogaster)
Homologues of Ub-K-IREB2 [cytosol]
(Sus scrofa)
Irp-1B [cytosol]
(Drosophila melanogaster)
Ub-K-IREB2 [cytosol]
(Caenorhabditis elegans)
Ub-K-IREB2 [cytosol]
(Dictyostelium discoideum)
Ub-K-IREB2 [cytosol]
(Mus musculus)
Ub-K-IREB2 [cytosol]
(Plasmodium falciparum)
Ub-K-IREB2 [cytosol]
(Rattus norvegicus)
Ub-K-IREB2 [cytosol]
(Sus scrofa)
Ub-K-IREB2 [cytosol]
(Xenopus tropicalis)
Irp-1A [cytosol]
(Drosophila melanogaster)
IREB2 [cytosol]
(Bos taurus)
IREB2 [cytosol]
(Canis familiaris)
IREB2 [cytosol]
(Gallus gallus)
IREB2 [cytosol]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_004127.1
,
NP_001307870.1
,
NP_001307872.1
ENSEMBL
ENST00000258886
,
ENST00000560440
,
ENSP00000258886
,
ENSP00000452938
OpenTargets
ENSG00000136381
HPA
ENSG00000136381-IREB2
PRO
P48200
Pharos - Targets
P48200
HMDB Protein
HMDBP01819
PDB
6VCD
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43353 ALDH3B1
3
ALDH3B1 [secretory granule membrane]
(R-HSA-6801023)
ALDH3B1 [plasma membrane]
(R-HSA-5696096)
ALDH3B1 [specific granule membrane]
(R-HSA-6799510)
0.527
2
UniProt:P51460 INSL3
2
INSL3(21-55) [extracellular region]
(R-HSA-444906)
INSL3(106-131) [extracellular region]
(R-HSA-444880)
0.527
2
UniProt:Q9NXU5 ARL15
0.527
2
UniProt:Q96S94 CCNL2
0.527
2
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