Cullin-associated NEDD8-dissociated protein 1 (CANDI, TIP120) is a key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, acting as a F-box protein exchange factor. CANDI binds cullin-1 (CUL1), preventing its association with SKP1 thereby disrupting the formation of SCF complexes. Neddylated CUL1 prevents CANDI binding (Zheng et al. 2002, Goldenberg et al. 2004).
Liu, J, Cascio, TC, Zheng, N, Xiong, Y, Shumway, SD, Garbutt, KC, Goldenberg, SJ
Lykke-Andersen, K, Harrell, JM, Ryzhikov, S, Sun, H, Wei, N, Shim, EH, Zheng, J, Zhang, H, Yang, X, Kobayashi, R
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