Reactome | CANDI binds CUL1

CANDI binds CUL1

Stable Identifier

R-HSA-5691131

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cullin-associated NEDD8-dissociated protein 1 (CANDI, TIP120) is a key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, acting as a F-box protein exchange factor. CANDI binds cullin-1 (CUL1), preventing its association with SKP1 thereby disrupting the formation of SCF complexes. Neddylated CUL1 prevents CANDI binding (Zheng et al. 2002, Goldenberg et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15537541	Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases Liu, J, Cascio, TC, Zheng, N, Xiong, Y, Shumway, SD, Garbutt, KC, Goldenberg, SJ	Cell	2004
12504026	CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex Lykke-Andersen, K, Harrell, JM, Ryzhikov, S, Sun, H, Wei, N, Shim, EH, Zheng, J, Zhang, H, Yang, X, Kobayashi, R	Mol. Cell	2002