Reactome | SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2

SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2

Stable Identifier

R-HSA-5691108

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2

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Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex containing the F-box/LRR-repeat protein 5 (FBXL5) protein (SKP1:FBXL5:CUL1:NEDD8) targets iron-responsive element-binding protein 2 (IREB2) for proteasomal degradation in iron-replete cells (Vashisht et al. 2009, Salahudeen et al. 2009). Cullin-1 (CUL1) is in neddylated form (NEDD8) which allows it to associate with this complex.

Literature References

PubMed ID	Title	Journal	Year
19762596	Control of iron homeostasis by an iron-regulated ubiquitin ligase Leibold, EA, Sun, D, Sangfelt, O, Bhaskaran, N, Powers, DN, Huang, X, Wohlschlegel, JA, Spruck, C, Durazo, A, Vashisht, AA, Zumbrennen, KB, Uhlén, M, Persson, A	Science	2009
19762597	An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis Ma, HW, Salahudeen, AA, Kinch, LN, Ruiz, JC, Li, Q, Grishin, NV, Bruick, RK, Thompson, JW	Science	2009