Reactome | SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2

SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2

Stable Identifier

R-HSA-5691108

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2

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Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex containing the F-box/LRR-repeat protein 5 (FBXL5) protein (SKP1:FBXL5:CUL1:NEDD8) targets iron-responsive element-binding protein 2 (IREB2) for proteasomal degradation in iron-replete cells (Vashisht et al. 2009, Salahudeen et al. 2009). Cullin-1 (CUL1) is in neddylated form (NEDD8) which allows it to associate with this complex.

Literature References

PubMed ID	Title	Journal	Year
19762596	Control of iron homeostasis by an iron-regulated ubiquitin ligase Vashisht, AA, Zumbrennen, KB, Huang, X, Powers, DN, Durazo, A, Sun, D, Bhaskaran, N, Persson, A, Uhlén, M, Sangfelt, O, Spruck, C, Leibold, EA, Wohlschlegel, JA	Science	2009
19762597	An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis Salahudeen, AA, Thompson, JW, Ruiz, JC, Ma, HW, Kinch, LN, Li, Q, Grishin, NV, Bruick, RK	Science	2009