Mitochondrial ferritin (FTMT) is specifically taken up by the mitochondria and processed to a mature protein that assembles into functional ferritin shells. It is a homooligomer of 24 subunits, is roughly spherical and contains a central cavity into which the mineral iron core is deposited. FTMT possesses ferroxidase activity. Iron is taken up in the ferrous form (Fe2+) and deposited as ferric hydroxide (Fe(3+)O(OH)) after oxidation. FTMT may play an important role in the regulation of iron homeostasis in the mitochondrion (Levi et al. 2001, Langlois d'Estaintot et al. 2004).
Drysdale, J, Bosisio, M, Arosio, P, Levi, S, Sanford, D, Corsi, B, Volz, A, Invernizzi, R
Santambrogio, P, Précigoux, G, Gallois, B, Arosio, P, Levi, S, Granier, T, Chevalier, JM, Langlois d'Estaintot, B
ferroxidase activity of FTMT 24mer [mitochondrial matrix]
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