Reactome | FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)

FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)

Stable Identifier

R-HSA-5691107

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)

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Mitochondrial ferritin (FTMT) is specifically taken up by the mitochondria and processed to a mature protein that assembles into functional ferritin shells. It is a homooligomer of 24 subunits, is roughly spherical and contains a central cavity into which the mineral iron core is deposited. FTMT possesses ferroxidase activity. Iron is taken up in the ferrous form (Fe2+) and deposited as ferric hydroxide (Fe(3+)O(OH)) after oxidation. FTMT may play an important role in the regulation of iron homeostasis in the mitochondrion (Levi et al. 2001, Langlois d'Estaintot et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
11323407	A human mitochondrial ferritin encoded by an intronless gene Drysdale, J, Bosisio, M, Arosio, P, Levi, S, Sanford, D, Corsi, B, Volz, A, Invernizzi, R	J. Biol. Chem.	2001
15201052	Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala Santambrogio, P, Précigoux, G, Gallois, B, Arosio, P, Levi, S, Granier, T, Chevalier, JM, Langlois d'Estaintot, B	J. Mol. Biol.	2004