Reactome | 5'- incision of DNA by ERCC1:ERCC4 in GG-NER

5'- incision of DNA by ERCC1:ERCC4 in GG-NER

Stable Identifier

R-HSA-5690990

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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5'- incision of DNA by ERCC1:ERCC4 in GG-NER

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In global genome nucleotide excision repair (GG-NER), just like in transcription-coupled nucleotide excision repair (TC-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by the ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision (Staresincic et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19279666	Coordination of dual incision and repair synthesis in human nucleotide excision repair Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD	EMBO J.	2009