5'- incision of DNA by ERCC1:ERCC4 in GG-NER

Stable Identifier
R-HSA-5690990
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
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Summation

In global genome nucleotide excision repair (GG-NER), just like in transcription-coupled nucleotide excision repair (TC-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by the ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision (Staresincic et al. 2009).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
nucleotide-excision repair, DNA incision, 3'-to lesion (0006295)
Catalyst Activity
Catalyst Activity
Title
endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
Physical Entity
GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
Activity
endonuclease activity (0004519)
Orthologous Events
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Arabidopsis thaliana)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Oryza sativa)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Saccharomyces cerevisiae)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Taeniopygia guttata)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)