5'- incision of DNA by ERCC1:ERCC4 in GG-NER

Stable Identifier
R-HSA-5690990
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
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Summation

In global genome nucleotide excision repair (GG-NER), just like in transcription-coupled nucleotide excision repair (TC-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by the ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision (Staresincic et al. 2009).

Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD

EMBO J. 2009
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
nucleotide-excision repair, DNA incision, 3'-to lesion (0006295)
Catalyst Activity
Catalyst Activity
Title
endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
Physical Entity
GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
Activity
endonuclease activity (0004519)
Orthologous Events
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Arabidopsis thaliana)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Oryza sativa)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Saccharomyces cerevisiae)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Taeniopygia guttata)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)
Authored
Joshi-Tope, G  (2003-07-14)
Hoeijmakers, JH  (2004-01-29)
Orlic-Milacic, M  (2015-06-16)
Reviewed
Fousteri, M  (2015-08-03)