5'- incision of DNA by ERCC1:ERCC4 in GG-NER

Stable Identifier
R-HSA-5690990
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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5'- incision of DNA by ERCC1:ERCC4 in GG-NER
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In global genome nucleotide excision repair (GG-NER), just like in transcription-coupled nucleotide excision repair (TC-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by the ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision (Staresincic et al. 2009).
Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Wijgers, N, Staresincic, L, Schärer, OD, Gourdin, AM, Fagbemi, AF, Enzlin, JH, Dunand-Sauthier, I, Clarkson, SG, Giglia-Mari, G, Vermeulen, W

EMBO J. 2009
Participants
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Output
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as an event of
Event Information
Go Biological Process
nucleotide-excision repair (0006289)
Catalyst Activity

endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm]

Physical Entity
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
Activity
endonuclease activity (GO:0004519)
Orthologous Events
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Plasmodium falciparum)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-06-16)
Joshi-Tope, G  (2003-07-14)
Hoeijmakers, JH  (2004-01-29)
Reviewed
Fousteri, M  (2015-08-03)
Created
Orlic-Milacic, M  (2015-05-04)
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