5'- incision of DNA by ERCC1:ERCC4 in GG-NER

Stable Identifier
R-HSA-5690990
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In global genome nucleotide excision repair (GG-NER), just like in transcription-coupled nucleotide excision repair (TC-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by the ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision (Staresincic et al. 2009).

Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Wijgers, N, Staresincic, L, Schärer, OD, Gourdin, AM, Fagbemi, AF, Enzlin, JH, Dunand-Sauthier, I, Clarkson, SG, Giglia-Mari, G, Vermeulen, W

EMBO J. 2009
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Participates
Event Information
Catalyst Activity

endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm]

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