5'- incision of DNA by ERCC1:ERCC4 in GG-NER

Stable Identifier
R-HSA-5690990
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In global genome nucleotide excision repair (GG-NER), just like in transcription-coupled nucleotide excision repair (TC-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by the ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision (Staresincic et al. 2009).

Literature References
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events