ACO1:4Fe-4S isomerises CIT to ISCIT

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytoplasmic aconitate hydratase (ACO1, iron regulatory protein 1, IRP1) functions either as an RNA binding protein that regulates the uptake, sequestration, and utilisation of iron or an enzyme that isomerises citrate to isocitrate, depending on changes in cellular iron levels. Under iron-replete conditions, ACO1 binds the cofactor 4Fe-4S cluster and acts as an aconitase, isomerising citrate (CIT) to isocitrate (ISCIT) (Kaptain et al. 1991, Philpott et al. 1994, Dupuy et al. 2006).
Literature References
PubMed ID Title Journal Year
16407072 Crystal structure of human iron regulatory protein 1 as cytosolic aconitase

Fontecilla-Camps, JC, Darnault, C, Carpentier, P, Volbeda, A, Dupuy, J, Moulis, JM

Structure 2006
1946430 A regulated RNA binding protein also possesses aconitase activity

Haile, D, Downey, WE, Orloff, DG, Harford, JB, Philpott, C, Kaptain, S, Klausner, RD, Rouault, TA, Tang, C

Proc. Natl. Acad. Sci. U.S.A. 1991
8041788 The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation

Philpott, CC, Klausner, RD, Rouault, TA

Proc. Natl. Acad. Sci. U.S.A. 1994
25550467 Cytosolic aconitase activity sustains adipogenic capacity of adipose tissue connecting iron metabolism and adipogenesis

Ortega, F, Moreno-Navarrete, JM, Fernández-Real, JM, Moreno, M, Xifra, G, Ricart, W

FASEB J 2015
Catalyst Activity

aconitate hydratase activity of ACO1:4Fe-4S [cytosol]

Orthologous Events
Cross References
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