Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IREB2 [cytosol]
Stable Identifier
R-HSA-5690876
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Iron-responsive element-binding protein 2, IREB2_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)
ACO1, IREB2 [cytosol] (Homo sapiens)
IREB2 [cytosol] (Homo sapiens)
ACO1, IREB2:TFRC, ALAD, FTL, FTH1 mRNAs [cytosol] (Homo sapiens)
ACO1, IREB2 [cytosol] (Homo sapiens)
IREB2 [cytosol] (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)
IREB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48200 IREB2
Gene Names
IREB2
Chain
chain:1-963
Reference Genes
BioGPS Gene:3658 IREB2
COSMIC (genes):IREB2 IREB2
CTD Gene:3658 IREB2
dbSNP Gene:3658 IREB2
ENSEMBL:ENSG00000136381 IREB2
ENSEMBL_homo_sapiens_GENE:ENSG00000136381.13 IREB2
HGNC:6115 IREB2
KEGG Gene (Homo sapiens):3658 IREB2
Monarch:3658 IREB2
NCBI Gene:3658 IREB2
OMIM:147582 IREB2
UCSC:P48200 IREB2
Reference Transcript
RefSeq:NM_001320941.1 IREB2
RefSeq:NM_001320943.1 IREB2
RefSeq:NM_004136.3 IREB2
Other Identifiers
11721363_x_at
11721364_s_at
11721365_a_at
11752798_a_at
11756521_a_at
11762719_at
1555476_PM_at
1555476_at
16803501
214666_PM_x_at
214666_x_at
225892_PM_at
225892_at
242261_PM_at
242261_at
3444509
3444545
3603337
3603341
3603348
3603349
3603352
3603355
3603357
3603359
3603360
3603361
3603362
3603363
3603364
3603365
3603366
3603367
3603368
3603369
3603371
3603373
3603374
3603375
3603376
3603377
3603378
3603379
3603380
3603381
3603382
3603384
3603385
3658
40345_at
4053677
54426_r_at
61344_at
63505_at
7985166
A_14_P133217
A_23_P106497
A_33_P3221528
GE58993
GO:0002376
GO:0003723
GO:0003824
GO:0003994
GO:0005515
GO:0005737
GO:0005739
GO:0005829
GO:0006091
GO:0006099
GO:0006101
GO:0006417
GO:0006782
GO:0006879
GO:0009791
GO:0010468
GO:0016071
GO:0016829
GO:0022600
GO:0030154
GO:0030316
GO:0030350
GO:0034101
GO:0043226
GO:0046872
GO:0048255
GO:0048856
GO:0050892
GO:0051536
GO:0051539
GO:0051649
GO:0055065
GO:0060586
HMNXSV003003049
Hs.295789.0.A1_3p_at
Hs.295789.0.A1_3p_x_at
Hs.295789.1.A1_3p_at
Hs.94149.0.S1_3p_at
Hs2.370324.1.S1_3p_at
ILMN_1726554
PH_hs_0017771
TC15000729.hg
TC15002301.hg
Participates
as a member of
ACO1, IREB2 [cytosol] (Homo sapiens)
as an input of
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)
Other forms of this molecule
Ub-K-IREB2 [cytosol]
Inferred To
Irp-1B [cytosol]
(Drosophila melanogaster)
Irp-1A [cytosol]
(Drosophila melanogaster)
IREB2 [cytosol]
(Bos taurus)
IREB2 [cytosol]
(Caenorhabditis elegans)
IREB2 [cytosol]
(Canis familiaris)
IREB2 [cytosol]
(Dictyostelium discoideum)
IREB2 [cytosol]
(Gallus gallus)
IREB2 [cytosol]
(Mus musculus)
IREB2 [cytosol]
(Plasmodium falciparum)
IREB2 [cytosol]
(Rattus norvegicus)
IREB2 [cytosol]
(Sus scrofa)
IREB2 [cytosol]
(Xenopus tropicalis)
Homologues of IREB2 [cytosol]
(Drosophila melanogaster)
Homologues of IREB2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001307872.1
,
NP_004127.1
,
NP_001307870.1
OpenTargets
ENSG00000136381
HPA
ENSG00000136381-IREB2
GeneCards
P48200
Ensembl
ENST00000560440
,
ENSG00000136381
,
ENST00000258886
,
ENSP00000452938
,
ENSP00000258886
PRO
P48200
Pharos - Targets
P48200
Orphanet
27153
PDB
6VCD
HMDB Protein
HMDBP01819
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43353 ALDH3B1
3
ALDH3B1 [plasma membrane]
(R-HSA-5696096)
ALDH3B1 [secretory granule membrane]
(R-HSA-6801023)
ALDH3B1 [specific granule membrane]
(R-HSA-6799510)
0.527
2
UniProt:P51460 INSL3
2
INSL3(21-55) [extracellular region]
(R-HSA-444906)
INSL3(106-131) [extracellular region]
(R-HSA-444880)
0.527
2
UniProt:Q9NXU5 ARL15
0.527
2
UniProt:Q96S94 CCNL2
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text