Reactome | TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1

TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1

Stable Identifier

R-HSA-5690856

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1

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TNFAIP3 (A20) removes lysine-63 (K63)-linked ubiquitin chains from Receptor interacting protein (RIPK1), an essential mediator of the proximal TNF receptor 1 (TNFR1) signalling complex. The carboxy-terminal domain of A20 then functions as a ubiquitin ligase, polyubiquitinating RIPK1 with K48-linked ubiquitin chains, thereby targeting RIPK1 for proteasomal degradation (Wertz et al. 2004) which leads to termination of TNF- or LPS-mediated activation of NF-kappa-B.

Literature References

PubMed ID	Title	Journal	Year
15258597	De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling Wertz, IE, O'Rourke, KM, Zhou, H, Eby, M, Aravind, L, Seshagiri, S, Wu, P, Wiesmann, C, Baker, R, Boone, DL, Ma, A, Koonin, EV, Dixit, VM	Nature	2004