Reactome | TNIPs bind TNFAIP3 (A20)

TNIPs bind TNFAIP3 (A20)

Stable Identifier

R-HSA-5690845

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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TNFAIP3-interacting protein (TNIPs), also known as A20-binding inhibitors of NF-kappa-B activation (ABINs), bind TNFAIP3, the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein A20 (Heyninck et al. 1999). Overexpression of TNIPs inhibits NF-kappaB activation by tumor necrosis factor (TNF). TNIPs have a ubiquitin-binding domain that is essential for their NF-kappaB inhibitory and anti-apoptotic activities. They may function as adaptors between ubiquitinated proteins and other regulatory proteins, or disrupt signaling complexes by competing with other ubiquitin-binding proteins (Verstrepen et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
10385526	The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN Heyninck, K, De Valck, D, Vanden Berghe, W, Van Criekinge, W, Contreras, R, Fiers, W, Haegeman, G, Beyaert, R	J. Cell Biol.	1999
19464428	ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling Verstrepen, L, Carpentier, I, Verhelst, K, Beyaert, R	Biochem. Pharmacol.	2009