Reactome | OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA

OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA

Stable Identifier

R-HSA-5690843

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA

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OTUB1 (and OTUB2) can bind TP53 ( Sun et al. 2012) RNF128 (GRAIL) (Soares et al. 2009), TRAF3 and TRAF6 (Li et al. 2010) and RhoA (Edelmann et al. 2010). OTUB1 has DUB activity but mainly acts by suppressing ubiquitin-conjugating E2 enzymes, independently of its catalytic activity (Sun & Dai 2014).

Literature References

PubMed ID	Title	Journal	Year
22124327	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1 Challagundla, KB, Sun, XX, Dai, MS	EMBO J.	2012
20553488	Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion Altun, M, Kessler, BM, Edelmann, MJ, Kramer, HB	FEBS J.	2010
19996094	Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6 Mao, AP, Zheng, H, Li, S, Shu, HB, Gao, Y, Tien, P, Ran, Y, Liu, Y, Li, Y, Zhong, B	J. Biol. Chem.	2010
14661020	Two isoforms of otubain 1 regulate T cell anergy via GRAIL Skrenta, H, Lovelace, P, Seroogy, C, Engleman, E, Soares, L, Chung, CD, Anandasabapathy, N, Fathman, CG	Nat. Immunol.	2004