OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

OTUB1 (and OTUB2) can bind TP53 ( Sun et al. 2012) RNF128 (GRAIL) (Soares et al. 2009), TRAF3 and TRAF6 (Li et al. 2010) and RhoA (Edelmann et al. 2010). OTUB1 has DUB activity but mainly acts by suppressing ubiquitin-conjugating E2 enzymes, independently of its catalytic activity (Sun & Dai 2014).

Literature References
PubMed ID Title Journal Year
22124327 Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

Challagundla, KB, Sun, XX, Dai, MS

EMBO J. 2012
20553488 Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion

Altun, M, Kessler, BM, Edelmann, MJ, Kramer, HB

FEBS J. 2010
19996094 Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6

Mao, AP, Zheng, H, Li, S, Shu, HB, Gao, Y, Tien, P, Ran, Y, Liu, Y, Li, Y, Zhong, B

J. Biol. Chem. 2010
14661020 Two isoforms of otubain 1 regulate T cell anergy via GRAIL

Skrenta, H, Lovelace, P, Seroogy, C, Engleman, E, Soares, L, Chung, CD, Anandasabapathy, N, Fathman, CG

Nat. Immunol. 2004
Orthologous Events
Cite Us!