DNA polymerases delta, epsilon or kappa bind the GG-NER site

Stable Identifier
R-HSA-5690213
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The DNA repair synthesis complex, consisting of PCNA, RFC, RPA and polymerase delta (POLD) or epsilon (POLE) complexes, or DNA translesion synthesis polymerase kappa (POLK) (Ogi et al. 2010), is formed at the nucleotide excision repair (NER) site following the incision of the damaged DNA strand 5' to the lesion by the ERCC1:ERCC4 (ERCC1:XPF) complex. 3' incision by XPG (ERCC5) is not required for the loading of the DNA polymerases and may not be required for the initiation of NER-mediated DNA synthesis (Staresincic et al. 2009). XPG and RPA promote the assembly of the DNA synthesis complex at the NER site (Mocquet et al. 2008).

Literature References
PubMed ID Title Journal Year
18079701 Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step

Mocquet, V, Lainé, JP, Riedl, T, Yajin, Z, Lee, MY, Egly, JM

EMBO J. 2008
20227374 Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

Ogi, T, Limsirichaikul, S, Overmeer, RM, Volker, M, Takenaka, K, Cloney, R, Nakazawa, Y, Niimi, A, Miki, Y, Jaspers, NG, Mullenders, LH, Yamashita, S, Fousteri, M, Lehmann, AR

Mol. Cell 2010
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD

EMBO J. 2009
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