Reactome | DNA polymerases delta, epsilon or kappa bind the GG-NER site

DNA polymerases delta, epsilon or kappa bind the GG-NER site

Stable Identifier

R-HSA-5690213

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DNA polymerases delta, epsilon or kappa bind the GG-NER site

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The DNA repair synthesis complex, consisting of PCNA, RFC, RPA and polymerase delta (POLD) or epsilon (POLE) complexes, or DNA translesion synthesis polymerase kappa (POLK) (Ogi et al. 2010), is formed at the nucleotide excision repair (NER) site following the incision of the damaged DNA strand 5' to the lesion by the ERCC1:ERCC4 (ERCC1:XPF) complex. 3' incision by XPG (ERCC5) is not required for the loading of the DNA polymerases and may not be required for the initiation of NER-mediated DNA synthesis (Staresincic et al. 2009). XPG and RPA promote the assembly of the DNA synthesis complex at the NER site (Mocquet et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
20227374	Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells Ogi, T, Limsirichaikul, S, Overmeer, RM, Volker, M, Takenaka, K, Cloney, R, Nakazawa, Y, Niimi, A, Miki, Y, Jaspers, NG, Mullenders, LH, Yamashita, S, Fousteri, M, Lehmann, AR	Mol. Cell	2010
18079701	Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step Mocquet, V, Lainé, JP, Riedl, T, Yajin, Z, Lee, MY, Egly, JM	EMBO J.	2008
19279666	Coordination of dual incision and repair synthesis in human nucleotide excision repair Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD	EMBO J.	2009