USP8 deubiquitinates RNF128

Stable Identifier
R-HSA-5690196
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The ubiquitin E3 ligase RNF128 (GRAIL) is regulated by auto-K48-linked ubiquitination, which leads to its proteasomal degradation. RNF128 is bound but not deubiquitinated by OTUB1. USP8 binds the RNF128:OTUB1 complex to remove the ubiquitin attached to GRAIL (Soares et al. 2004, Whiting et al. 2011).

Literature References
PubMed ID Title Journal Year
14661020 Two isoforms of otubain 1 regulate T cell anergy via GRAIL

Soares, L, Seroogy, C, Skrenta, H, Anandasabapathy, N, Lovelace, P, Chung, CD, Engleman, E, Fathman, CG

Nat. Immunol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP8:K48polyUb-RNF128:OTUB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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