Reactome | USP8 deubiquitinates RNF128

USP8 deubiquitinates RNF128

Stable Identifier

R-HSA-5690196

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The ubiquitin E3 ligase RNF128 (GRAIL) is regulated by auto-K48-linked ubiquitination, which leads to its proteasomal degradation. RNF128 is bound but not deubiquitinated by OTUB1. USP8 binds the RNF128:OTUB1 complex to remove the ubiquitin attached to GRAIL (Soares et al. 2004, Whiting et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
14661020	Two isoforms of otubain 1 regulate T cell anergy via GRAIL Soares, L, Seroogy, C, Skrenta, H, Anandasabapathy, N, Lovelace, P, Chung, CD, Engleman, E, Fathman, CG	Nat. Immunol.	2004