USP16,USP21 deubiquitinate Histone H2A

Stable Identifier
R-HSA-5690157
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP16 and USP21 can associate with and deubiquitinate H2A (Joo et al. 2007, Zhang et al. 2014, Nakagawa et al. 2008).

Literature References
PubMed ID Title Journal Year
18172164 Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

Nakagawa, T, Kajitani, T, Togo, S, Masuko, N, Ohdan, H, Hishikawa, Y, Koji, T, Matsuyama, T, Ikura, T, Muramatsu, M, Ito, T

Genes Dev. 2008
25305019 The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage

Zhang, Z, Yang, H, Wang, H

J. Biol. Chem. 2014
Participants
Participates
Catalyst Activity

thiol-dependent ubiquitin-specific protease activity of USP16,USP21:Ub-histone H2A [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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