USP16,USP21 deubiquitinate Histone H2A

Stable Identifier
R-HSA-5690157
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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USP16,USP21 deubiquitinate Histone H2A
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USP16 and USP21 can associate with and deubiquitinate H2A (Joo et al. 2007, Zhang et al. 2014, Nakagawa et al. 2008).

Literature References
PubMed ID Title Journal Year
18172164 Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

Nakagawa, T, Kajitani, T, Togo, S, Masuko, N, Ohdan, H, Hishikawa, Y, Koji, T, Matsuyama, T, Ikura, T, Muramatsu, M, Ito, T

Genes Dev. 2008
25305019 The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage

Zhang, Z, Yang, H, Wang, H

J. Biol. Chem. 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP16,USP21:Ub-histone H2A [nucleoplasm]
Physical Entity
USP16,USP21:Ub-histone H2A [nucleoplasm]
Activity
thiol-dependent ubiquitinyl hydrolase activity (0036459)
Orthologous Events
USP16,USP21 deubiquitinate Histone H2A (Bos taurus)
USP16,USP21 deubiquitinate Histone H2A (Caenorhabditis elegans)
USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)
USP16,USP21 deubiquitinate Histone H2A (Danio rerio)
USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)
USP16,USP21 deubiquitinate Histone H2A (Mus musculus)
USP16,USP21 deubiquitinate Histone H2A (Plasmodium falciparum)
USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)
USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-04-27)
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