USP5 cleaves polyubiquitin

Stable Identifier
R-HSA-5690152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP5 (Isopeptidease T) cleaves linear and branched polyubiquitin (polyUb) with a preference for branched polymers (Wilkonson et al. 1995). It is Involved in the disassembly of unattached lysine-48-linked (K48) polyUb. It also binds linear and K63-linked polyUb with a lower affinity (Dayal et al. 2009).

Literature References
PubMed ID Title Journal Year
7578059 Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

Wilkinson, KD, Tashayev, VL, O'Connor, LB, Larsen, CN, Kasperek, E, Pickart, CM

Biochemistry 1995
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP5:PolyUb [cytosol]

Orthologous Events
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