USP3,SAGA deubiquitinate Histone H2A,H2B

Stable Identifier
R-HSA-5690080
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP3 dynamically associates with chromatin and deubiquitinates H2A and H2B in vivo. The ZnF-UBP domain of USP3 mediates the H2A-USP3 interaction (Nicassio et al. 2007). USP22, a component of the hSAGA transcriptional coactivator complex, is able to deubiquitinate Histone H2A and H2B (Zhang et al. 2008, Zhao et al. 2008).

Literature References
PubMed ID Title Journal Year
17980597 Human USP3 is a chromatin modifier required for S phase progression and genome stability

Nicassio, F, Corrado, N, Vissers, JH, Areces, LB, Bergink, S, Marteijn, JA, Geverts, B, Houtsmuller, AB, Vermeulen, W, Di Fiore, PP, Citterio, E

Curr. Biol. 2007
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm]

Orthologous Events
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