USP3 dynamically associates with chromatin and deubiquitinates H2A and H2B in vivo. The ZnF-UBP domain of USP3 mediates the H2A-USP3 interaction (Nicassio et al. 2007). USP22, a component of the hSAGA transcriptional coactivator complex, is able to deubiquitinate Histone H2A and H2B (Zhang et al. 2008, Zhao et al. 2008).
Houtsmuller, AB, Corrado, N, Di Fiore, PP, Marteijn, JA, Vissers, JH, Nicassio, F, Citterio, E, Geverts, B, Bergink, S, Vermeulen, W, Areces, LB
cysteine-type deubiquitinase activity of USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm]
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