USP3,SAGA deubiquitinate Histone H2A,H2B

Stable Identifier
R-HSA-5690080
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP3 dynamically associates with chromatin and deubiquitinates H2A and H2B in vivo. The ZnF-UBP domain of USP3 mediates the H2A-USP3 interaction (Nicassio et al. 2007). USP22, a component of the hSAGA transcriptional coactivator complex, is able to deubiquitinate Histone H2A and H2B (Zhang et al. 2008, Zhao et al. 2008).

Literature References
PubMed ID Title Journal Year
17980597 Human USP3 is a chromatin modifier required for S phase progression and genome stability

Nicassio, F, Corrado, N, Vissers, JH, Areces, LB, Bergink, S, Marteijn, JA, Geverts, B, Houtsmuller, AB, Vermeulen, W, Di Fiore, PP, Citterio, E

Curr. Biol. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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