Reactome | USP3,SAGA deubiquitinate Histone H2A,H2B

USP3,SAGA deubiquitinate Histone H2A,H2B

Stable Identifier

R-HSA-5690080

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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USP3,SAGA deubiquitinate Histone H2A,H2B

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USP3 dynamically associates with chromatin and deubiquitinates H2A and H2B in vivo. The ZnF-UBP domain of USP3 mediates the H2A-USP3 interaction (Nicassio et al. 2007). USP22, a component of the hSAGA transcriptional coactivator complex, is able to deubiquitinate Histone H2A and H2B (Zhang et al. 2008, Zhao et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
17980597	Human USP3 is a chromatin modifier required for S phase progression and genome stability Nicassio, F, Corrado, N, Vissers, JH, Areces, LB, Bergink, S, Marteijn, JA, Geverts, B, Houtsmuller, AB, Vermeulen, W, Di Fiore, PP, Citterio, E	Curr. Biol.	2007