Reactome | USP10,USP24,USP42 deubiquitinate TP53

USP10,USP24,USP42 deubiquitinate TP53

Stable Identifier

R-HSA-5689973

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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USP10 specifically deubiquitinate p53 and not MDM2 (Yuan et al. 2010). USP24 and USP42 also can deubiquitinate p53, regulating the DNA damage response following UV-damage (Hock et al. 2011, Zhang et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
20096447	USP10 regulates p53 localization and stability by deubiquitinating p53 Lou, Z, Cheville, JC, Yuan, J, Luo, K, Zhang, L	Cell	2010
22085928	Regulation of p53 stability and function by the deubiquitinating enzyme USP42 Carter, S, Vigneron, AM, Ludwig, RL, Hock, AK, Vousden, KH	EMBO J.	2011
25578727	The deubiquitinating enzyme USP24 is a regulator of the UV damage response Harris, TK, Lubin, A, Zhang, L, Gong, F, Nemzow, L, Sun, Z, Rong, X, Chen, H	Cell Rep	2015