USP10,USP24,USP42 deubiquitinate TP53

Stable Identifier
R-HSA-5689973
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP10 specifically deubiquitinate p53 and not MDM2 (Yuan et al. 2010). USP24 and USP42 also can deubiquitinate p53, regulating the DNA damage response following UV-damage (Hock et al. 2011, Zhang et al. 2015).

Literature References
PubMed ID Title Journal Year
22085928 Regulation of p53 stability and function by the deubiquitinating enzyme USP42

Hock, AK, Vigneron, AM, Carter, S, Ludwig, RL, Vousden, KH

EMBO J. 2011
20096447 USP10 regulates p53 localization and stability by deubiquitinating p53

Yuan, J, Luo, K, Zhang, L, Cheville, JC, Lou, Z

Cell 2010
25578727 The deubiquitinating enzyme USP24 is a regulator of the UV damage response

Zhang, L, Nemzow, L, Chen, H, Lubin, A, Rong, X, Sun, Z, Harris, TK, Gong, F

Cell Rep 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP10,USP24,USP42:PolyUb-TP53 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created