Reactome | USP2 deubiquitinates MDM2,MDM4

USP2 deubiquitinates MDM2,MDM4

Stable Identifier

R-HSA-5689972

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)

General

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The ubiquitin protease USP2 deubiquitinates MDM2 and MDM4 but not TP53 (Stevenson et al. 2007, Allende-Vega et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19838211	MdmX is a substrate for the deubiquitinating enzyme USP2a Allende-Vega, N, Sparks, A, Saville, MK, Lane, DP	Oncogene	2010
17290220	The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 Saville, MK, Lane, DP, Sparks, A, Xirodimas, DP, Stevenson, LF, Allende-Vega, N	EMBO J.	2007