USP2 deubiquitinates MDM2,MDM4

Stable Identifier
R-HSA-5689972
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The ubiquitin protease USP2 deubiquitinates MDM2 and MDM4 but not TP53 (Stevenson et al. 2007, Allende-Vega et al. 2010).

Literature References
PubMed ID Title Journal Year
17290220 The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Stevenson, LF, Sparks, A, Allende-Vega, N, Xirodimas, DP, Lane, DP, Saville, MK

EMBO J. 2007
19838211 MdmX is a substrate for the deubiquitinating enzyme USP2a

Allende-Vega, N, Sparks, A, Lane, DP, Saville, MK

Oncogene 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created