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GPI-FOLR1 [ER to Golgi transport vesicle membrane]
Stable Identifier
R-HSA-5689806
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ER to Golgi transport vesicle membrane
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15328 FOLR1
Gene Names
FOLR1, FOLR
Chain
signal peptide:1-24, chain:25-234, propeptide:235-257
Reference Genes
BioGPS Gene:2348 FOLR1
COSMIC (genes):FOLR1 FOLR1
CTD Gene:2348 FOLR1
dbSNP Gene:2348 FOLR1
ENSEMBL:ENSG00000110195 FOLR1
ENSEMBL_homo_sapiens_GENE:ENSG00000110195.14 FOLR1
HGNC:3791 FOLR1
KEGG Gene (Homo sapiens):2348 FOLR1
Monarch:2348 FOLR1
NCBI Gene:2348 FOLR1
OMIM:136430 FOLR1
UCSC:P15328 FOLR1
Reference Transcript
RefSeq:NM_016724.2 FOLR1
RefSeq:NM_016729.2 FOLR1
RefSeq:NM_000802.3 FOLR1
RefSeq:NM_016725.2 FOLR1
Other Identifiers
11717928_a_at
11717929_s_at
11717930_x_at
16728632
204437_PM_s_at
204437_s_at
2348
3339409
3339411
3339412
3339413
3339414
3339415
3339416
3339417
3339418
3339419
3339420
39311_at
534_s_at
7942332
821_s_at
A_14_P125003
A_23_P53176
GE54019
GE58998
GO:0000139
GO:0001947
GO:0003147
GO:0003253
GO:0005515
GO:0005542
GO:0005576
GO:0005615
GO:0005634
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006575
GO:0006766
GO:0006898
GO:0007155
GO:0007342
GO:0009897
GO:0009986
GO:0012507
GO:0015884
GO:0016020
GO:0016192
GO:0016323
GO:0016324
GO:0017015
GO:0022414
GO:0023052
GO:0030133
GO:0030136
GO:0030154
GO:0031103
GO:0031410
GO:0031526
GO:0033116
GO:0035036
GO:0038023
GO:0038024
GO:0043226
GO:0046655
GO:0048678
GO:0048856
GO:0048870
GO:0060089
GO:0060828
GO:0061024
GO:0061626
GO:0061713
GO:0061714
GO:0070062
GO:0071231
GO:0098552
HMNXSV003026439
ILMN_1661733
ILMN_1698608
ILMN_1712582
ILMN_2346339
PH_hs_0004211
TC11000754.hg
TC11002773.hg
U20391_rna6_at
U78793_at
g2565195_3p_s_at
g9257206_3p_a_at
Participates
as a member of
GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Homo sapiens)
Other forms of this molecule
GPI-FOLR1 [Golgi membrane]
GPI-FOLR1 [transport vesicle]
GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GPI-FOLR1 [endoplasmic reticulum membrane]
Inferred To
LOC609612 [ER to Golgi transport vesicle membrane]
(Canis familiaris)
GPI-FOLR1 [ER to Golgi transport vesicle membrane]
(Gallus gallus)
GPI-FOLR1 [ER to Golgi transport vesicle membrane]
(Mus musculus)
FOLR3 [ER to Golgi transport vesicle membrane]
(Bos taurus)
FOLR1 [ER to Golgi transport vesicle membrane]
(Sus scrofa)
Folr1 [ER to Golgi transport vesicle membrane]
(Rattus norvegicus)
Modified Residues
Name
L-serine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 201
Coordinate
201
Modification
GPI-anchor amidated amino acid carboxyl end residue(1−)
PsiMod Name
L-serine amide
PsiMod Definition
A protein modification that effectively converts an L-serine residue to L-serine amide.
Cross References
RefSeq
NP_057936.1
,
NP_057941.1
,
NP_057937.1
,
NP_000793.1
ZINC - World Drugs
FOLR1_HUMAN
Guide to Pharmacology - Targets
3212
OpenTargets
ENSG00000110195
ZINC - FDA approved
FOLR1_HUMAN
ZINC - Substances
FOLR1_HUMAN
ZINC target
P15328
ZINC - Biogenic
FOLR1_HUMAN
PRO
P15328
PDB
4KM7
,
4KM6
,
4LRH
,
5IZQ
,
4KMX
GeneCards
P15328
HPA
ENSG00000110195-FOLR1
Ensembl
ENSP00000377284
,
ENSP00000377281
,
ENSP00000377286
,
ENST00000393681
,
ENSP00000502440
,
ENSG00000110195
,
ENST00000393679
,
ENSP00000308137
,
ENST00000675784
,
ENST00000312293
,
ENST00000393676
Pharos - Targets
P15328
Orphanet
18926
ZINC - Predictions - Purchasable
FOLR1_HUMAN
HMDB Protein
HMDBP02326
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