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(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle]
Stable Identifier
R-HSA-5689724
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
COPII-coated ER to Golgi transport vesicle
Synonyms
Cathepsin C
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53634 CTSC
Gene Names
CTSC, CPPI
Chain
signal peptide:1-24, chain:25-134, propeptide:135-230, chain:231-394, chain:395-463
Reference Genes
BioGPS Gene:1075 CTSC
COSMIC (genes):CTSC CTSC
CTD Gene:1075 CTSC
dbSNP Gene:1075 CTSC
ENSEMBL:ENSG00000109861 CTSC
HGNC:2528 CTSC
KEGG Gene (Homo sapiens):1075 CTSC
Monarch:1075 CTSC
NCBI Gene:1075 CTSC
OMIM:602365 CTSC
UCSC:P53634 CTSC
Reference Transcript
RefSeq:NM_148170.4 CTSC
RefSeq:NM_001114173.2 CTSC
RefSeq:NM_001814.5 CTSC
Other Identifiers
0003450095
0003450600
0006420079
1075
11715710_s_at
11731465_a_at
11731466_a_at
133_at
16743111
201487_at
225646_at
225647_s_at
231234_at
2831981
3385770
3385771
3385774
3385776
3385777
3385778
3385779
3385780
3385781
3385782
3385783
3385788
3385791
3385794
3385795
3385796
3385805
63866_at
74213_at
7893937
7950906
A_23_P1552
A_24_P115762
A_33_P3268472
A_33_P3283480
GE61251
GE86110
GO:0000139
GO:0001913
GO:0002376
GO:0003674
GO:0004197
GO:0004252
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005813
GO:0005815
GO:0005856
GO:0006508
GO:0006810
GO:0006888
GO:0006915
GO:0006950
GO:0006955
GO:0007165
GO:0007568
GO:0008150
GO:0008219
GO:0008233
GO:0008234
GO:0009056
GO:0010033
GO:0016020
GO:0016192
GO:0016505
GO:0016787
GO:0019899
GO:0019902
GO:0022607
GO:0030134
GO:0030234
GO:0031012
GO:0031404
GO:0031410
GO:0031642
GO:0033116
GO:0035578
GO:0042802
GO:0043167
GO:0043226
GO:0043231
GO:0043312
GO:0043621
GO:0048208
GO:0048856
GO:0050877
GO:0051087
GO:0051603
GO:0061024
GO:0062023
GO:0065003
GO:0070062
GO:1903052
GO:1903980
GO:2001235
Hs.10029.1.S1_3p_at
ILMN_1689086
ILMN_1696347
ILMN_1792885
ILMN_2242463
PH_hs_0022406
PH_hs_0035561
TC11002175.hg
X87212_at
g4503140_3p_at
Participant Of
hasMember
glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle]
Other forms of this molecule
CTSC(25-134) [lysosomal lumen]
CTSC(25-134) [extracellular region]
CTSC(25-134) [azurophil granule lumen]
(Glc)3(GlcNAc)2(Man)9-CTSC [endoplasmic reticulum lumen]
(Glc)3(GlcNAc)2(Man)9-CTSC [endoplasmic reticulum-Golgi intermediate compartment membrane]
Inferred To
CTSC [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
ctsc [COPII-coated ER to Golgi transport vesicle] (Danio rerio)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Plasmodium falciparum)
(Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Xenopus tropicalis)
Ctsc [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
Ctsc [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
Homologues of (Glc)3(GlcNAc)2(Man)9-CTSC [COPII-coated ER to Golgi transport vesicle] (Plasmodium falciparum)
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position
Modification
N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Cross References
RefSeq
NP_001805.3
,
NP_680475.1
,
NP_001107645.1
OpenTargets
ENSG00000109861
HPA
ENSG00000109861-CTSC
GeneCards
P53634
ZINC - Substances
CATC_HUMAN
ZINC target
P53634
Ensembl
ENST00000227266
,
ENST00000524463
,
ENSP00000433539
,
ENST00000529974
,
ENSP00000227266
,
ENSP00000432541
,
ENSG00000109861
PRO
P53634
ZINC - Predictions - Purchasable
CATC_HUMAN
Orphanet
15822
HMDB Protein
HMDBP08180
PDB
1K3B
,
2DJF
,
3PDF
,
4CDD
,
4CDC
,
4OEL
,
2DJG
,
4OEM
,
4CDE
,
4CDF
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