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TIMMDC1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5689720
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Complex I assembly factor TIMMDC1, mitochondrial, TIDC1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O00217 NDUFS8
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
TIMMDC1 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
TIMMDC1 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPL8 TIMMDC1
Gene Names
TIMMDC1, C3orf1, UNQ247/PRO284
Chain
chain:1-285
Reference Genes
BioGPS Gene:51300 TIMMDC1
COSMIC (genes):TIMMDC1 TIMMDC1
CTD Gene:51300 TIMMDC1
dbSNP Gene:51300 TIMMDC1
ENSEMBL:ENSG00000113845 TIMMDC1
ENSEMBL_homo_sapiens_GENE:ENSG00000113845.10 TIMMDC1
HGNC:1321 TIMMDC1
KEGG Gene (Homo sapiens):51300 TIMMDC1
Monarch:51300 TIMMDC1
NCBI Gene:51300 TIMMDC1
OMIM:615534 TIMMDC1
UCSC:Q9NPL8 TIMMDC1
Reference Transcript
RefSeq:NM_016589.3 TIMMDC1
Other Identifiers
11757279_a_at
16944386
223004_PM_s_at
223004_s_at
227546_PM_x_at
2638018
2638019
2638020
2638021
2638025
2638026
2638028
2638029
2638032
2638034
2638037
2638038
2638039
49192_s_at
51300
8081867
A_14_P118040
A_14_P132374
A_23_P18413
GE54904
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005743
GO:0016020
GO:0031966
GO:0043226
HMNXSV003051924
Hs.76239.3.A1_3p_s_at
ILMN_2193175
PH_hs_0023057
TC03000609.hg
g12003267_3p_a_at
Participates
as an input of
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
as an output of
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
as a component of
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
Inferred To
Timmdc1 [mitochondrial inner membrane]
(Mus musculus)
Timmdc1 [mitochondrial inner membrane]
(Rattus norvegicus)
TIMMDC1 [mitochondrial inner membrane]
(Bos taurus)
TIMMDC1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
TIMMDC1 [mitochondrial inner membrane]
(Canis familiaris)
TIMMDC1 [mitochondrial inner membrane]
(Gallus gallus)
TIMMDC1 [mitochondrial inner membrane]
(Sus scrofa)
timmdc1 [mitochondrial inner membrane]
(Danio rerio)
timmdc1 [mitochondrial inner membrane]
(Xenopus tropicalis)
140up [mitochondrial inner membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_057673.2
OpenTargets
ENSG00000113845
GeneCards
Q9NPL8
HPA
ENSG00000113845-TIMMDC1
Ensembl
ENST00000494664
,
ENSP00000418803
,
ENSG00000113845
PRO
Q9NPL8
Pharos - Targets
Q9NPL8
Orphanet
24983
Interactors (79)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q969F0 FATE1
0.666
4
UniProt:Q9NX14 NDUFB11
1
NDUFB11 [mitochondrial inner membrane]
(R-HSA-163933)
0.666
4
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.643
5
UniProt:Q9P032 NDUFAF4
1
NDUFAF4 [mitochondrial inner membrane]
(R-HSA-5689124)
0.643
4
UniProt:Q9Y375 NDUFAF1
1
NDUFAF1 [mitochondrial inner membrane]
(R-HSA-5689050)
0.643
5
UniProt:Q9H845 ACAD9
1
ACAD9 [mitochondrial inner membrane]
(R-HSA-5689049)
0.643
5
UniProt:Q9NX47 MARH5
0.556
3
UniProt:Q96HP8 T176A
0.556
3
UniProt:Q96KR6 F210B
0.556
3
UniProt:Q14802-3 FXYD3
0.556
3
UniProt:Q9Y225-2 RNF24
0.556
3
UniProt:Q6PI78 TMM65
0.556
3
UniProt:Q8WVX3-2 C4ORF3
0.556
3
UniProt:Q8WW34-2 TMEM239
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q969K7 TMM54
0.556
3
UniProt:Q8N6R1 SERP2
0.556
3
UniProt:Q86Y82 STX12
0.556
3
UniProt:Q969S6 TM203
0.556
3
UniProt:Q8TAZ6 CKLF2
0.556
3
UniProt:Q16849-3 PTPRN
0.556
3
UniProt:Q6UW88-2 Q6UW882
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8TAF8 LHFPL5
1
LHFPL5 [plasma membrane]
(R-HSA-9658860)
0.556
3
UniProt:O75063 XYLK
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:Q6ICL7 S35E4
0.556
3
UniProt:O75787 ATP6AP2
3
ATP6AP2 [plasma membrane]
(R-HSA-2022356)
ATP6AP2 [tertiary granule membrane]
(R-HSA-6799717)
ATP6AP2 [ficolin-1-rich granule membrane]
(R-HSA-6800921)
0.556
3
UniProt:P50542-3 PEX5
0.556
3
UniProt:Q6UWT4 CE046
0.556
3
UniProt:Q8N6S5 AR6P6
0.556
3
UniProt:Q8TAC9 SCAM5
0.556
3
UniProt:P13236 CCL4
1
CCL4(24-92) [extracellular region]
(R-HSA-443976)
0.556
3
IntAct:EBI-22326698 CCSB ORF ID
0.556
3
UniProt:O95236-2 APOL3
0.556
3
UniProt:Q92982 NINJ1
0.556
3
UniProt:Q8TD06 AGR3
0.556
3
UniProt:Q9HCS2 CYP4F12
1
CYP4F12 [endoplasmic reticulum membrane]
(R-HSA-211015)
0.556
3
UniProt:Q5BVD1 TTMP
0.556
3
UniProt:P01563 IFNA2
1
IFNA2 [extracellular region]
(R-HSA-877349)
0.556
3
UniProt:Q9Y548 YIPF1
0.556
3
UniProt:Q8N511 TM199
0.556
3
UniProt:Q8TDV0 GP151
0.556
3
UniProt:Q8N357 S35F6
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:Q86WB7-2 UNC93A
0.556
3
UniProt:Q8N912 NRAC
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:Q96PD2-2 DCBLD2
0.556
3
UniProt:Q5SR56 MF14B
0.556
3
UniProt:Q8N682 DRAM1
0.556
3
UniProt:Q96JF0-2 ST6GAL2
0.556
3
UniProt:O75920 SERF1
0.556
3
UniProt:Q7Z5S9 TM144
0.556
3
UniProt:Q07326 PIGF
1
PIGF [endoplasmic reticulum membrane]
(R-HSA-162819)
0.556
3
UniProt:Q9NYZ1 TV23B
0.556
3
UniProt:Q8N2M4 TM86A
0.556
3
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.556
3
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.556
3
UniProt:Q99706 KIR2DL4
1
KIR2DL4 [plasma membrane]
(R-HSA-197726)
0.556
3
UniProt:P29033 GJB2
3
GJB2 [plasma membrane]
(R-HSA-53211)
GJB2 [endoplasmic reticulum membrane]
(R-HSA-1629779)
GJB2 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190614)
0.556
3
UniProt:P55056 APOC4
1
APOC4 [extracellular region]
(R-HSA-5215930)
0.556
3
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.556
3
UniProt:O00767 SCD
1
SCD [endoplasmic reticulum membrane]
(R-HSA-400117)
0.556
3
UniProt:P51572 BCAP31
6
BCAP31 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985503)
BCAP31 [endoplasmic reticulum membrane]
(R-HSA-9714333)
BCAP31(2-245) [endoplasmic reticulum membrane]
(R-HSA-201587)
BCAP31(165-237) [endoplasmic reticulum membrane]
(R-HSA-351909)
BCAP31(2-164) [endoplasmic reticulum membrane]
(R-HSA-351826)
BCAP31(238-246) [cytosol]
(R-HSA-351912)
0.556
3
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.556
3
UniProt:O95674 CDS2
1
CDS2 [mitochondrial inner membrane]
(R-HSA-1498755)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q86W74-2 ANKRD46
0.556
3
UniProt:O75251 NDUFS7
1
NDUFS7 [mitochondrial matrix]
(R-HSA-6788521)
0.527
2
UniProt:O00217 NDUFS8
1
NDUFS8 [mitochondrial matrix]
(R-HSA-6788526)
0.527
2
UniProt:O75306 NDUFS2
1
NDUFS2 [mitochondrial matrix]
(R-HSA-6788520)
0.527
2
UniProt:O95298 NDUFC2
3
NDUFC2 [plasma membrane]
(R-HSA-6806276)
NDUFC2 [azurophil granule membrane]
(R-HSA-6799211)
NDUFC2 [mitochondrial inner membrane]
(R-HSA-59860)
0.527
2
UniProt:Q8IUX1 TMEM126B
1
TMEM126B [mitochondrial inner membrane]
(R-HSA-5689046)
0.527
2
UniProt:O43674 NDUFB5
1
NDUFB5 [mitochondrial inner membrane]
(R-HSA-163944)
0.527
2
UniProt:Q9BU61 NDUFAF3
1
NDUFAF3 [mitochondrial inner membrane]
(R-HSA-5689126)
0.527
3
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.527
3
UniProt:Q9P0J0 NDUFA13
8
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
NDUFA13(41-49) [mitochondrial inner membrane]
(R-HSA-9839958)
NDUFA13(100-108) [mitochondrial inner membrane]
(R-HSA-9839959)
NDUFA13(109-144) [mitochondrial inner membrane]
(R-HSA-9839968)
NDUFA13(2-19) [mitochondrial inner membrane]
(R-HSA-9839966)
NDUFA13(69-99) [mitochondrial inner membrane]
(R-HSA-9839964)
NDUFA13(20-40) [mitochondrial inner membrane]
(R-HSA-9839963)
NDUFA13(50-68) [mitochondrial inner membrane]
(R-HSA-9839961)
0.527
3
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.527
4
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