Reactome | AIFM2 [mitochondrial outer membrane]

AIFM2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-5689128

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Apoptosis-inducing factor 2 ecNumber1.-.-.-/ecNumber, AIFM2_HUMAN, AMID, PRG3

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates AIFM2 gene expression (Homo sapiens)
        
        AIFM2 [mitochondrial outer membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BRQ8 AIFM2

Gene Names

AIFM2, AMID, PRG3

Chain

initiator methionine:1, chain:2-373

Reference Genes

BioGPS Gene:84883 AIFM2

COSMIC (genes):AIFM2 AIFM2

CTD Gene:84883 AIFM2

dbSNP Gene:84883 AIFM2

ENSEMBL:ENSG00000042286 AIFM2

HGNC:21411 AIFM2

KEGG Gene (Homo sapiens):84883 AIFM2

Monarch:84883 AIFM2

NCBI Gene:84883 AIFM2

OMIM:605159 AIFM2

UCSC:Q9BRQ8 AIFM2

Reference Transcript

Other Identifiers

0002650095

11723707_a_at

11723708_at

11744648_s_at

11762491_at

16715088

224461_PM_s_at

224461_s_at

228445_PM_at

228445_at

3293188

3293190

3293191

3293192

3293193

3293194

3293196

3293198

3293201

3293203

3293204

3293205

3293207

3293211

3293212

50745_at

76151_at

7934101

84883

A_23_P138567

A_32_P75094

A_33_P3319231

GE61752

GO:0003674

GO:0003677

GO:0004174

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005741

GO:0005811

GO:0005829

GO:0005886

GO:0006091

GO:0006743

GO:0006950

GO:0007005

GO:0008150

GO:0008219

GO:0008637

GO:0016020

GO:0016021

GO:0016491

GO:0016655

GO:0022904

GO:0031966

GO:0043065

GO:0043167

GO:0043226

GO:0044281

GO:0050660

GO:0110076

GO:1900407

HMNXSV003010171

HMNXSV003054927

Hs.117062.0.A1_3p_at

ILMN_1712639

PH_hs_0006413

TC10001359.hg

g13543963_3p_s_at

Participates

as an output of

TP53 stimulates AIFM2 gene expression (Homo sapiens)

Cross References

RefSeq

NP_001185625.1, NP_116186.1

OpenTargets

ENSG00000042286

HPA

ENSG00000042286-AIFM2

GeneCards

Q9BRQ8

Ensembl

ENSG00000042286, ENSP00000312370, ENSP00000478931, ENST00000373248, ENST00000307864, ENST00000613322, ENSP00000362345

PRO

Q9BRQ8

Pharos - Targets

Q9BRQ8

HMDB Protein

HMDBP08261

Interactors (3)

Accession	Confidence Score	Evidence (IntAct)
UniProt:Q86WT6-2 TRIM69	0.556	3
UniProt:Q9BYV2 TRI54	0.556	3
UniProt:Q8N129 CNPY4	0.556	3

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