Reactome | AIFM2 [mitochondrial outer membrane]

AIFM2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-5689128

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Apoptosis-inducing factor 2 ecNumber1.-.-.-/ecNumber, AIFM2_HUMAN, AMID, PRG3

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates AIFM2 gene expression (Homo sapiens)
        
        AIFM2 [mitochondrial outer membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BRQ8 AIFM2

Gene Names

AIFM2, AMID, PRG3

Chain

initiator methionine:1, chain:2-373

Reference Genes

BioGPS Gene:84883 AIFM2

COSMIC (genes):AIFM2 AIFM2

CTD Gene:84883 AIFM2

dbSNP Gene:84883 AIFM2

ENSEMBL:ENSG00000042286 AIFM2

ENSEMBL_homo_sapiens_GENE:ENSG00000042286 AIFM2

HGNC:21411 AIFM2

KEGG Gene (Homo sapiens):84883 AIFM2

Monarch:84883 AIFM2

NCBI Gene:84883 AIFM2

OMIM:605159 AIFM2

UCSC:Q9BRQ8 AIFM2

Reference Transcript

Other Identifiers

0002650095

11723707_a_at

11723708_at

11744648_s_at

11762491_at

16715088

224461_s_at

228445_at

28961

3293188

3293191

3293192

3293193

3293194

3293196

3293198

3293201

3293203

3293204

3293205

3293207

3293211

42309

50745_at

76151_at

7934101

84883

A_23_P138567

A_32_P75094

A_33_P3319231

AAH06121

AAH23601

AAL73229

AAM77596

AF337957

AF506757

AIFM2

AIFM2-201

AIFM2-202

AIFM2-204

AK027403

AK127353

AL731540

BAB55089

BAG54492

BC006121

BC023601

BX537621

CAH56481

CCDS7297

CH471083

EAW54376

ENSG00000042286

ENSP00000312370

ENSP00000362345

ENSP00000478931

ENST00000307864

ENST00000307864.2

ENST00000373248

ENST00000373248.5

ENST00000613322

ENST00000613322.4

EntrezGene:84883

g13543963_3p_s_at

GE61752

GO:0003674

GO:0003677

GO:0004174

GO:0005575

GO:0005615

GO:0005737

GO:0005739

GO:0005741

GO:0005811

GO:0005829

GO:0006091

GO:0006915

GO:0007005

GO:0008219

GO:0008637

GO:0016020

GO:0016021

GO:0016491

GO:0022904

GO:0042981

GO:0043065

GO:0043167

GO:0043226

GO:0050660

GO:0055114

HGNC:21411

HPA028961

HPA042309

Hs.117062.0.A1_3p_at

ILMN_1712639

IPR000103

IPR023753

IPR036188

MIM:605159

NM_001198696

NM_032797

NP_001185625

NP_116186

PF07992

PH_hs_0006413

PR00368

PR00469

TC10001359.hg

UPI000003F07F

Participant Of

output

TP53 stimulates AIFM2 gene expression

Cross References

RefSeq

NP_001185625.1, NP_116186.1

OpenTargets

ENSG00000042286

GeneCards

Q9BRQ8

PRO

Q9BRQ8

HMDB Protein

HMDBP08261

Interactors (4)

Accession	Confidence Score	Evidence (IntAct)
UniProt:Q86WT6-2 TRIM69	0.488	2
UniProt:Q1A5X7 WHAL1	0.488	2
UniProt:Q9BYV2 TRI54	0.488	2
UniProt:Q8N129 CNPY4	0.488	2